不同剂量阿托伐他汀对急性心肌梗死患者早期炎症反应临床探究.docVIP

不同剂量阿托伐他汀对急性心肌梗死患者早期炎症反应临床探究【摘要】 目的 探讨不同剂量阿托伐他汀早期干预治疗对急性心肌梗死患者血脂及血清高敏C反应蛋白的影响。方法 60例AMI患者随机分为大剂量阿托伐他汀(40 mg/d)治疗组(30例)和常规剂量阿托伐他汀(20 mg/d)治疗组(30例),分别在入院24 h内及服药后3、7 d测定患者血脂、高敏C反应蛋白,比较两组患者血脂、高敏C反应蛋白的变化。结果 治疗7 d后20 mg/d及40 mg/d阿托伐他汀治疗组总胆固醇、低密度脂蛋白水平较治疗前有降低(P0.05)。结论 早期大剂量阿托伐他汀应用更能降低急性心肌梗死患者的高敏C反应蛋白水平,且阿托伐他汀的抗炎治疗独立于降脂之外。 【关键词】 阿托伐他汀;血脂;高敏C反应蛋白;急性心肌梗死 The Clinical study of atorvastatin therapy of different doses on hs-CRP leves in patients in early phase with acute myocardial infarction HUANG Qi-lei,WANG Guang-you,JIANG Ling.Department of Cardiology,Fujian Medical University Affiliated Teaching Hospital,Nanping First Hospital,Nanping 35300,China 【Abstract】 Objective To investigate the effect of different doses of atorvastatinon on serum high sensitivity C-reactive protein and blood lipid levels in early phase of acute myocardial infarction.Methods A total of 60 patients with AMI were randomly assigned into the large dosage of atorvastatin(40 mg/d)group(n=30)and the routine dosage ofatorvastatin(20 mg/d)(n=30).Serum levels of blood lipid,hs-CRP were measured with biochemistry assay 24 hour after admission and 3 days and 7 days after therapy.The difference in blood lipid,hs-CRP was compared between the two groups.Results Among the two groups,the levels of TC and LDL-C decreased significandy after treatment(P 1.4.3 统计学方法 计量资料以均数±标准差(x±s)表示,检测结果各组组内及组间比较采用t检验,所有数据以SPSSl3.0统计软件分析,P0.05),血清hs-CRP显著下降(P0.05),血清hs-CRP显著下降(P 1