“抛砖引玉”-2.pdf

二、如何才能做好科研？ 稳定的科研方向 不做井蛙做苍鹰 团结互助拧成绳 给学生一片蓝天 稳定的科研方向 Ischemia/Reperfusion Injury 和谐向上的集体 走出国门见世面，学来真经报祖国 Study contents and results (1) first time discovered existence of CaSR in rat cardiac tissue and its expression rule in rat with different age （2 ）first time discovered that acivition of CaSR could induce intracellular Ca by G-protein-PLC-IP3 pathway, which is a mechanism for calcium overload. （3 ）First revealed expression rule and critical role of CaSR in cardiac I/R injury and apoptosis through activating MAPKs ( p38, JNK,ERK) - cytochrome c – caspase-3 pathway and Fas receptor death pathway. A. Fas B. FasL （4 ）first time found that the change of CaSR activity mediated by PKCεis involved in cardiac protection induced by ischemic postconditioning. (A) control (B) I/R (C) IPC (D) PC (E) PC+GdCl3 (F) PC+PKCI (G) PC+GdCl3+PKCI （5 ）first discovered that CaSR expression is increased in cardiac hypertrophy, which signal is involved in CaN and PKC pathways 。 （6 ）first revealed that increase of CaSR expression in artherosclerosis rat induce increased sensitivity to AMI (7) first demonstrated that polyamine homeostasis is very important for myocardium ，and spermine in higher or lower concentration could induce myocardial damage, as a double edged sword. (8) first time demonstrated that exogenous spermine with low concentration possese protection for cardiac ischemia/ reperfusion injury. (9) first time demonstrated existance of CaSR functional expression in pulmonary artery and PAMSC. (10) first time demonstrated CaSR Mediates Hypoxia-InducedProliferation of Rat PASM CellsThrough MEK1⁄ERK1,2 and PI3K Pathways (11) first time demonstrated The functional expression of CaSR in the differentiated THP-1 cells 变压力为动力