药学专业毕业论文课件.docVIP

　　　　 中医药大学2010届中药学专业本科生 毕 业 论 文 ? 解郁散对大鼠抑郁模型行为学影响 Anti-depressive effect of jieyu decoction on chronic stress depression in rats 专 业： 姓 名： 指导老师： 实习单位： 　 目 录 目录 ……………………………………………………………………………1 中文摘要 ………………………………………………………………………2 英文摘要 ………………………………………………………………………3 前言 …………………………………………………………………………4 材料 ………………………………………………………………………5 动物 …………………………………………………………………5 药物 …………………………………………………………………5 仪器 …………………………………………………………………5 方法 ………………………………………………………………………6 2.1 动物分组 ……………………………………………………………6 2.2 抑郁大鼠模型的建立 ………………………………………………6 2.3 行为测定 ……………………………………………………………6 2.4 体液消耗实验 ………………………………………………………6 2.5 统计学处理 …………………………………………………………7 结果 ………………………………………………………………………7 讨论 ………………………………………………………………………8 参考文献 ……………………………………………………………………10 中文摘要 [摘要]目的:观察解郁散对慢性应激诱导的恶劣心境障碍模型大鼠行为的影响。方法:选择40只SD 雄性大鼠随机分为对照组、模型组、解郁散组和百忧解组共4 组,每组各10 只。应用分养和长期不可预见的中等强度应激造成大鼠恶劣心境障碍模型。以Open - Field 法和糖水消耗实验对照研究慢性应激诱导的恶劣心境障碍模型大鼠行为的改变。结果:与对照组比较,模型组大鼠Open - Field 评分降低,糖水消耗量减少;与模型组比较,各治疗组大鼠在治疗后Open - Field 评分升高,糖水消耗量增加。结论:解郁散可改变分养和长期不可预见的中等强度应激诱导的恶劣心境障碍模型大鼠的抑郁行为,提示解郁散具有一定的抗抑郁作用。 [关键词] 抑郁症 应激 大鼠模型 Abstract [Abstract]　objective To investigate the effect of jieyu decoction on behavior in the separation and chronic unpredictable mild stress - induced Dysthymic rat model. Methods Male Sprague - Dauley rats were randomly allocated to four groups as follows :control ,model ,Fluoxetine and jieyu decoction. The Dysthymic model of rat was produsde by separation and chronic unpredictaboe mild stress. The behavior of rat was detected by open - field test. Open - field and sucrose consumption were used to study the chandges of rat behavior. Results The results showed that the Fluoxetine , jieyu decoction are increase after treatment. Conclusions These data suggest that jieyu decoction was effective in the treatment of Dysthymia. [Key words]　Depressio