阳明腑实证患者气血虚损与免疫失衡及预后的关系分析-relationship between deficiency of qi and blood, immune imbalance and prognosis in patients with yangming fu organ syndrome.docxVIP
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阳明腑实证患者气血虚损与免疫失衡及预后的关系分析-relationship between deficiency of qi and blood, immune imbalance and prognosis in patients with yangming fu organ syndrome
天津中医药大学硕士学位论文 天津中医药大学硕士学位论文 PAGE PAGE 1 中文摘要 目的:研究阳明腑实证患者气血虚损的严重程度,炎症免疫反应以及预后的差异, 以明确气血虚损与免疫失衡的关系,指导临床应用。 方法:选取 90 例从 2011 年 2 月至 2012 年 4 月天津市南开医院外科 ICU 病房收治 的符合阳明腑实证诊断的患者,根据中医辨证分型将患者分为气虚组(56 例)和血虚组 (34 例)。入组后第一天记录患者的体温、心率、呼吸、平均动脉压等生命体征以及急 性生理与慢性健康评分-Ⅱ(acute physiology and chronic health evaluation-Ⅱ,APACHE- Ⅱ)评分、脏器功能损伤数目,测定患者的白细胞计数(white blood cell,WBC)、人类 白细胞抗原 DR 位点(human leucocyte antigen-DR site,HLA-DR)及辅助性 T 细胞亚群 1(Helper T cells-1)和亚群 2(Helper T cells-1)、Th1/Th2,出院时统计两组患者住 ICU 时间、总住院时间、住院费用、预后的差异。 结果:首先,两组患者在性别、年龄及原发病的比较上,差异无统计学意义,在一 般情况及病情比较方面,气虚组 APACHE-Ⅱ评分、脏器功能损伤数目、平均动脉压低 于血虚组,中医见证积分、体温、心率高于血虚组;在炎症反应及免疫状态方面,气虚 组 WBC 低于血虚组,HLA-DR、Th1、Th2 高于血虚组;在预后比较方面,气虚组 ICU 住院时间、总住院时间、住院费用、病死率低于血虚组,各项指标比较,差异有统计学 意义(P0.05)。 结论:阳明腑实证患者气虚与血虚的差异能够在一定程度上反应患者的病情严重程 度,免疫失衡状态,以及转归预后等,气血辨证学说在临床中具有一定的辅助诊断价值。 关键词:阳明腑实证;气血虚损;免疫失衡;HLA-DR;辅助性 T 细胞亚群。 ABSTRACT Objective:To study the severity of Qi and Blood deficiency and the inflammatory immune response and prognostic differences of the Excessiveness of yangming fu(viscus) patients, in order to study the relationship of Qi and Blood deficiency with immune imbalance to guide clinical application. Method: 90 cases with Excessiveness of yangming fu(viscus) patients were observed in surgical intensive care unit Tianjin Nankai hospital from February 2011 to April 2012 , according to TCM syndrome type, patients were divided into qi deficiency group (n = 56) and blood deficiency group (n=34). The patients body temperature, heart rate, breathing, mean arterial blood pressure and other vital signs as well as the APACHE-II(acute physiology and chronic health evaluation-II, APACHE-II) score, and the determination of the patients white blood cell count (white blood cell WBC), human leukocyte antigen DR site (human leucocyte antigen-DR site, HLA-DR) and T helper cell subsets 1 (Th1) and subgroup 2 (Th2), Th1/Th2 were recorded, And statistic ICU stay time, the total length of hospital stay, cost of hospitalization, prognosis differences of two g
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