血管紧张素ii 1型受体基因a1166c多态性与脑梗死的关联研究-association between polymorphism of angiotensin ii type 1 receptor gene a 1166 c and cerebral infarction.docxVIP

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血管紧张素ii 1型受体基因a1166c多态性与脑梗死的关联研究-association between polymorphism of angiotensin ii type 1 receptor gene a 1166 c and cerebral infarction.docx

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血管紧张素ii 1型受体基因a1166c多态性与脑梗死的关联研究-association between polymorphism of angiotensin ii type 1 receptor gene a 1166 c and cerebral infarction

内蒙古科技大学包头医学院硕士学位论文内蒙古科技大学包头医学院硕士学位论文 PAGE PAGE 10 吸烟史发病的相对危险度（ OR）为 1.706(95%CI:0.924-3.148)，但 P ＞ 0.05，无统计学意义。 AC 基因与高血压两者有协同致脑梗死效应。结论：中国内蒙地区汉族人群 AT1R 基因 A1166C 单核苷酸多态性与脑梗死的发生有关系， AC 基因型为易患基因型；AT1R 基因 A1166C 单核苷酸多态性与高血压无关；高血压是脑梗死发病的独立危险因素；AC 基因型和高血压两者有协同致脑梗死效应。关键词：脑梗死；血管紧张素 II 1 型受体；基因多态性 Associated study between cerebral infarction and A1166C polymorphism of angiotensin II type 1 receptor gene Specialty： internal medicine（Neurology） Postgraduate ：Sun Hongying Directed by ： Prof.He Jiling Abstract Objective Angiotensin II type 1 receptor (AT1R) is one of the important factors in the process of blood pressure regulation, as well as in the damage of target organs. The mutations of AT1R gene lead to the changes of AT1R function. The current study was conduct to analyze the distribution characters of single nucleotide polymorphisms A1166C of AT1R gene (SNP), and to investigate the association between AT1R gene SNP and essential hypertension and cerebral infarction in Chinese Neimenggu Hans. The research was expected to provide the basis of identification of predisposing genes and prevention and cure for cerebral infarction. Methods A case-control study of 100 cases and 90 controls was carried out with molecular epidemiological and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The AT1R genotype and gene frequencies were analyzed, and further analyses were conducted according with hypertensive and without hypertensive.. Independent fatalness of AT1R genotypes and alleles toward hypertension and cerebral infarction were analyzed by Logistic regression. The coordinating function between Hypertension and genetic factors in the pathogenesis of cerebral infarction was analyzed by Logistic regression. Results The 2 genotypes in site 1166 of AT1R gene were identified among 190 individuals. The 1166C allele frequency of AT1R gene was 0.12 in cases and 0.044 in contr