iga肾病中磷酸化cjun氨基末端激酶与肾间质纤维化的关系-relationship between phosphorylated cjun amino-terminal kinase and renal interstitial fibrosis in iga nephropathy.docx

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2018-05-29 发布于上海
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iga肾病中磷酸化cjun氨基末端激酶与肾间质纤维化的关系-relationship between phosphorylated cjun amino-terminal kinase and renal interstitial fibrosis in iga nephropathy.docx

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iga肾病中磷酸化cjun氨基末端激酶与肾间质纤维化的关系-relationship between phosphorylated cjun amino-terminal kinase and renal interstitial fibrosis in iga nephropathy

transdifferentiationofrenaltubularepithelialcellsandinvolvesinthedevelopmentoftubulointerstitialfibrosisinpatientswithIgAN.TheexpressionofP-JNK,TGF-β1,α-SMA,FNandthescoreofTILwaspositivelycorrelatedwiththeexpressionofCTGF,theexpressionofTGF-β1,CTGF,FNandthescoreofTILwaspositivelycorrelatedwiththeexpressionofP-JNK,itclewsthatCTGFparticipatesintheTGF-β1-inducedmyofibroblastproliferationandextracellularmatrixdeposition,JNKinvolvesintheTGF-β1-ducedexpresstionofCTGFinrenaltubularepithelialcellsandinvolvesinthedevelopmentoftubulointerstitialfibrosisinpatientswithIgAN.TheexpressionofP-JNK,CTGFandα-SMAintubulointerstitialincreasesignificantlywiththetypeofIgANgettingserious,ithintsthatP-JNK,CTGFandα-SMAmaybeimportantindicestoreflectthepathogeneticconditionandprognosisofIgAN.Keywords：IgAN;Renaltubularepithelialcell;Transforminggrowthfactorbeta1;Connectivetissuegrowthfactor;phosphorylatedc-JunN-terminalkinase;α-smoothmuscleactin;Fibronectin缩略语表(abbreviations)缩略词α-SMA英文全称α-smoothmuscleactin中文全称α-平滑肌肌动蛋白AP-1Activatorprotein-1活化蛋白-1CTGFDABECMERKFNHEIgANJNKMAPKMCP-1MEKConneetivetissuegrowthfaetorDiaminobenzidinetetrahydrochlorideExtracellularmatrixExtracellularsignal-regulatedkinasFibronectinHematoxylin-eosinIgAnephropathyc-JunN-terminalkinaseMitogenactivatedproteinkinaseMonocytechemoattractantprotein-1MAPK/ERKkinase结缔组织生长因子四盐酸二氨联苯胺细胞外基质细胞外信号调节激酶纤维连接蛋白苏木素-伊红IgA肾病c-Jun氨基末端激酶丝裂原活化蛋白激酶单核细胞趋化蛋白-1MAPK/ERK激酶MFMKKMyofibroblastMAPKkinase肌成纤维细胞MAPK激酶MKKKMAPKkinasekinaseMAPK激酶激酶MMP-2Matrixmetalloproteinase-2基质金属蛋白酶-2PASPeriodicacid-schiff过碘酸雪夫反应PASMPBSPeriodicacid-silvermethenaminePhosphatebufferedsaline六胺银染色磷酸盐缓冲液P38P-JNKRIFTGF-β1P38mitogenactivatedproteinkinasePhosphorylatedc-JunN-terminalkinaseRenalinterstitialfibrosisTransforminggrowthfactorbeta1P38丝裂原活化蛋白激酶磷酸化c-Jun氨基末端激酶肾间质纤维化转化生长因子TEMTTubularepithelial-myofibroblast小管上皮肌成纤维细胞转分化TIFtransdifferentiationTubulointerstitialfibrosis小管间质纤维化TILUUOTubulo-interstitallesionsUnilateralureteralobstruction肾小管间质病变/损伤单侧输尿管梗阻II山西医科大学硕士学位论文学位论文独创性声明本人王