cyp17基因ins基因lhβ基因多态性与多囊卵巢综合征的相关分析word格式论文.docxVIP

PCOSgroup(P0.05),BMIlevelsofA1A2ismoresignificanthigherthanthatofA2A2andA1A1.(P0.05),WhileTESlevelsofA1A1seemsthehighest,andthatofA2A2isthelowest,andthestatisticaldifferenceissignificant(P0.05).ByLogisticregressionanalysis,wefoundA2A2genotypedidnotincreasetheriskof PCOSdisease.NosignificantdifferenceswereobservedbetweenthePCOScasesandcontrolsgroupseitherinallele(P=0.647)orgenotype(P=0.903)frequenciesof INS-VNTRpolymorphism;Regardinganthropometricdata,hormonelevels,and HOMA-IR there were no significant differences between INS-VNTR genotypesinthePCOSgroup,aswellasinthenon-PCOSgroup.TheLogisticregressionanalysisTT(III/III)genotypeanddidnotincreasetheriskofdiseasePCOS.alleleTRPandARGpresentnostatisticaldifferencebetweenthePCOSandN-PCOS groups . The mutation rate of TRP8ARG detected in the PCOSgroup(6cases)andcontrolgroup(4cases)were10.9％and8.0％，relatively，butthediferencebetweenthetwogroupswasnotstatisticallysignificant．Themutation rateofllel5ThrdetectedinthePCOSgroup(5cases)andcontrolgroup (4cases) were9.1％and8.0％，relatively．Thediferenceoffrequencyofmutationwasnotsignificantstatisticallytoo．TherewasalsonodiferencefoundinhormonallevelsbetweentheheterozygousandwildtypeinPCOS groupandcontrolgroup．ConclusionOurdatadoesnotsupportanassociationbetweenpolymorphismsofCYP17,INS,LHgenesandsusceptibilitytoPCOSorrelatedtraitsinGuangdong.childbearingwomen.Keywords：Polycysticovarysyndrome;Genepolymorphism;CYP17gene;INS gene,LHgene中英文对照词汇表英文缩写BMI英文全称Body-massindex中文体重指数PCOSPolycysticovarysyndrome多囊卵巢综合征SNPSingleNucleotidePolymorphisms单核苷酸多态性CYP17cytochromeP45017hydroxylase细胞色素P450C17酶有2种活性(17α羟化酶和17,20裂链酶)并由共同的基因CYP17编码INSinsulin胰岛素LHluteinizinghormone黄体生成素FSHfollicle-stimulatinghormone卵泡刺激素TEStestosterone睾酮IRInsulinResistance胰岛素抵抗HOMAHomeostasismodelassessment胰岛素抵抗指数RFLPRestrictionFragmentLengthPolymorphism多聚酶链反应-限制性片段长度多态性HWEHardy-WeinbergEquilibriumHardy-weinberg平衡VNTRVariableNumberofTandemRepeats可变串联重复序列学位论文原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进行研究工作所取得的成果。文中依法引用他人的成果、对本文的研究作出重要贡献的个