c met和mmp 11在胃癌组织中的表达与肝转移的关系word格式论文.docxVIP

新疆医科大学医学硕士学位论文The expression of C-Met and MMP-11 in gastric carcinoma and their relations to hepatic metastasisPostgraduate: baoguoxuSupervisor: Professor Yun-hai WangAbstractObjective To investigate the relationship between high expression of C-Met, MMP-11 and gastric cancer hepatic metastasis, and the connection of each factor. We hope we can do something in the early prediction of gastric cancer hepatic metastasis, intensive care and improve the prognosis. Methods Collected the clinical pathology data of 78 patients who were gastric cancer hepatic metastasis and 78 patients who were not gastric cancer hepatic metastasis at the same time in the first affiliated hospital of xinjiang medical university 2002 to 2008, then analyzed the data retrospectively. Checked the filed paraffin wax specimen and the pathologic diagnosis at least by 2 pathological attending physicians. We detected the C-Met, MMP-11 in gastric cancer specimen using in situ hybridization technique and immunohistochemistry technique in DNA and protein levels.Combining with the clinical pathology data, we progress χ2 test and Logistic regression toanalyze the Risk factor of gastric cancer hepatic metastasis. Results The result of single factor analysis of variance to clinical pathology data showed that gastric cancer hepatic metastasis correlated with the TNM stage of gastric cancer, general type, degree of differentiation, depth of infiltration, canalis haemalis infiltration, diameter of tumor andlymph node transfusion. The positive rate of C-Met mRNA、MMP-11 mRNA expressingin gastric cancer were 55.13%、56.41% respectively, the positive rate of their expressing in gastric cancer hepatic metastasis were 70.50%、75.60%, comparing with the non-gastric cancer hepatic metastasis,there were significant deviation (P=0.000) ; Meanwhile Theexpression of C-Met mRNA、MMP-11 mRNA correlated with canalis haemalis infiltration, lymph node transfusion, TNM stage; Of the total, the expression of MMP-11 mRNA correlate