但目前认为大量氧自由基生成,引发强烈的脂质.PDFVIP

美洛昔康对老年痴呆模型大鼠学习记忆能力及脑组织SOD，MAO-B ， MDA 的影响 李钟勇，张鹏( 四川省遂宁市中心医院，四川 遂宁 629000) 摘要：目的 探讨美洛昔康对老年痴呆模型大鼠抗痴呆作用及其作用机制。方法 采用慢性铝过负荷建立大鼠脑损伤老 年痴呆动物模型，通过每天给予大鼠灌胃葡萄糖酸铝(Al3 ＋200 mg·kg1)溶液，每周持续5 d ，连续灌胃20 周建立老年痴 呆大鼠动物模型；根据大鼠体重每千克给予3 mg 或 1 mg 美洛昔康的比例，在大鼠灌胃给予铝后进行美洛昔康溶液灌胃。 建模成功后，分别观察大鼠空间学习记忆能力、海马病理形态学变化及大鼠脑组织SOD，MAO-B 活性和MDA 含量。结 果 老年痴呆模型大鼠学习记忆能力明显下降、海马神经元损伤，而在大鼠脑组织中MDA 含量及MAO-B 活性则呈现明 显升高趋势，同时大鼠脑组织SOD 活性则显著降低。给予美洛昔康能明显改善老年痴呆模型大鼠的学习记忆能力，减轻 大鼠海马神经元细胞损伤，同时使老年痴呆大鼠脑组织MDA 含量明显减少，而大鼠脑组织MAO-B 活性升高及SOD 活 性降低的趋势得到明显遏制。结论 美洛昔康使老年痴呆模型大鼠学习记忆能力有明显的改善，对老年痴呆模型大鼠有 作者简介：李钟勇，男，主管药师 Tel:E-mail: snlzy789@163.com 中国现代应用药学2011 年2 月第28 卷第2 期 Chin JMAP, 2011 February, Vol.28 No.2 ·99 · 显著的保护作用。 关键词：老年痴呆；美洛昔康；慢性铝过负荷；保护 中图分类号：R965.1 文献标志码：A 文章编号：1007-7693(2011)02-0099-05 Effects of Meloxicam on Learning, Memory and Expression of SOD, MAO-B and MDA in Brain Tissue of Alzheimer’s Disease Model Rats LI Zhongyong, ZHANG Peng(Suining Central Hospital, Suining 629000, China) ABSTRACT: OBJECTIVE To study the protective effect of meloxicam on brain damage of Alzheimer’s disease(AD) model rats. METHODS The AD model rats were established via intragastric administration of aluminum gluconate (element aluminum 200 mg·kg1) once a day, 5 d a week for 20 weeks. Given 3 mg meloxicam per kg rat body weight and 1 mg meloxicam per kg rat after gavage given aluminum. After the success of modeling, pathomorphological changes of hippocampal neuron and the spatial learning and memory ability of rats were determined. The SOD, MAO-B activities, and the MDA contents of brain tissue in rats were measured. RESULTS The AD model rats’ spatial learning and memory ability was significantly decreased and hippocampal neuronal injury in rats. In the rat brain tissue, the MAO-B activities and the MDA content was significantly increased, at the same time, the SOD activities of rat brain tissue was significa