Best Linear Unbiased Prediction of Genomic Breeding Values Using a Trait-Specific Marker-Derived Relationship Matrix精品.pdfVIP
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Best Linear Unbiased Prediction of Genomic Breeding Values Using a Trait-Specific Marker-Derived Relationship Matrix精品
Best Linear Unbiased Prediction of Genomic Breeding
Values Using a Trait-Specific Marker-Derived
Relationship Matrix
1,2 1 1 3 2 1
Zhe Zhang , Jianfeng Liu , Xiangdong Ding , Piter Bijma , Dirk-Jan de Koning *, Qin Zhang *
1 Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China,
2 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, United Kingdom, 3 Animal Breeding and Genomics Centre,
Wageningen University, Wageningen, The Netherlands
Abstract
Background: With the availability of high density whole-genome single nucleotide polymorphism chips, genomic selection
has become a promising method to estimate genetic merit with potentially high accuracy for animal, plant and aquaculture
species of economic importance. With markers covering the entire genome, genetic merit of genotyped individuals can be
predicted directly within the framework of mixed model equations, by using a matrix of relationships among individuals
that is derived from the markers. Here we extend that approach by deriving a marker-based relationship matrix specifically
for the trait of interest.
Methodology/Principal Findings: In the framework of mixed model equations, a new best linear unbiased prediction
(BLUP) method including a trait-specific relationship matrix (TA) was presented and termed TABLUP. The TA matrix was
constructed on the basis of marker genotypes and their weights in relation to the trait of interest. A simulation study with
1,000 individuals as the training population and five successive generations as candidate population was carried out to
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