影响新生儿Ⅱ型房间隔缺损自然愈合危险因素的-中华临床医师杂志.PDFVIP

²2232 ² 中华临床医师杂志( 电子版)2016 年8 月第10 卷第15 期 Chin J Clinicians(Electronic Edition),August 1,2016,Vol.10,No.15 ²临床论著² 影响新生儿Ⅱ型房间隔缺损自然愈合 危险因素的临床研究 1 1 2 2 管琰 杨磊 钱建清 陈健 【摘要】 目的 探讨和寻找影响新生儿房间隔自然愈合的危险因素。方法 收集301 例在常 熟市第一人民医院确诊为Ⅱ型房间隔缺损的新生儿，制定规律的随访计划，纳入性别、缺损位置、 缺损大小、缺损数量、并发症为可能存在的相关危险因素，通过单因素分析和多因素逐步 Logistic 回归分析影响新生儿房间隔缺损自然愈合的独立危险因素。结果 301 例Ⅱ型房间隔缺损新生儿有 24 例房间隔缺损在随访结束时仍未自然愈合，经单因素分析筛选出缺损位置、缺损大小、合并肺动 脉高压为有统计学意义的危险因素，进一步经多因素逐步 Logistic 回归分析得出缺损位置（腔静脉 窦型）、缺损大小（＞4 mm ）、合并肺动脉高压是影响新生儿Ⅱ型房间隔缺损自然愈合的独立危险 因素。结论 腔静脉窦型房间隔缺损、缺损大小＞4 mm、合并肺动脉高压是影响新生儿房间隔缺损 自然愈合的独立危险因素，对于缺损位置为腔静脉窦型、缺损＞4 mm 及合并肺动脉高压的新生儿应 及时制定更为积极的随访和治疗方案，这有望提高患儿今后的生存质量。 【关键词】 房间隔缺损； 自然愈合； 危险因素 Risk factors of affecting spontaneous closure of secundum atrial septal defect in newborn: a 1 1 2 2 1 case-control study Guan Yan , Yang Lei , Qian Jianqing , Chen Jian . Department of Function, 2Department of Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 215500, China Corresponding author: Guan Yan, Email: szc163.com 【Abstract 】 Objective To explore and find the risk factors affecting the spontaneous closure of secundum atrial septal defect in newborn. Methods Collected 301 cases diagnosed in our hospital for type Ⅱ atrial septal defect in newborn, follow-up plan was strict formulation, the risk factors included gender, location, size, quantity, and complications were the possible risk factors. Through single factor analysis and multiple factor stepwise Logistic regression analysis, the independent risk factors of spontaneous closure of type Ⅱ atrial septal defect were