丙型肝炎性肝硬化患者血清内脏脂肪素的表达意义.docVIP

丙型肝炎性肝硬化患者血清内脏脂肪素的表达意义 　　[摘要] 目的 分析丙型肝炎性肝硬化患者血清内脏脂肪素的表达意义。 方法 收集河北省沧州市中心医院2014年7月～2015年11月117例丙型肝炎性肝硬化患者（肝硬化组，A级41例、B级42例、C级34例）和20例健康对照人员（对照组）为研究对象，测量两组被试人员的血清内脏脂肪素、胰岛素抵抗指数（HOMA-IR）、白介素-6（IL-6）水平。 结果 肝硬化组及A、B、C三级患者内脏脂肪素水平低于对照组，HOMA-IR和IL-6水平高于对照组，差异有统计学意义（P 0.05），HOMA-IR和IL-6水平比较，差异有统计学意义（P 0.05）。 结论 丙型肝炎性肝硬化患者的内脏脂肪素表达水平较低，内脏脂肪素可作为诊断丙型肝炎性肝硬化的指标，但是不能作为判断肝功能严重程度的指标。 　　[关键词] 丙型肝炎；肝硬化；内脏脂肪素；Child-Pugh分级；胰岛素抵抗 　　[中图分?号] R657.3+1 [文献标识码] A [文章编号] 1673-7210（2016）12（a）-0062-04 　　Significance of serum levels of visfatin in patients with hepatitis C cirrhosis 　　WEI Xinliang WANG Weiwei WEI Sichen KONG Yu TIAN Shuying JIANG Hongyu 　　The Second Digestive Department of Internal Medicine， Central Hospital of Cangzhou City， Hebei Province， Cangzhou 061000， China 　　[Abstract] Objective To analyze the significance of serum levels of visfatin in patients with hepatitis C cirrhosis. Methods 117 cases of hepatitis C cirrhosis patients （Liver cirrhosis group， A level 41 cases，B level 42 cases and C level 34 cases） and 20 healthy controls （control group） were collected in Central Hospital of Cangzhou City from July 2014 to November 2015. The serum levels of HOMA-IR， IL-6 and visfatin in two groups were measured. Results The levels of visfatin in A， B， C three level and liver cirrhosis group were lower than those in the control group， HOMA-IR and IL-6 levels were higher than those in the control group， the difference was statistically significant （P 0.05）， HOMA-IR and IL-6 levels were significantly different （P 0.05）. Conclusion The expression of visfatin in patients with hepatitis C cirrhosis is lower， and visfatin can be used as an index to diagnose hepatitis C cirrhosis， but it can not be used as an index to judge the severity of liver function. 　　[Key words] Hepatitis C； Liver cirrhosis； Visfatin； Child-Pugh classification； Insulin resistance 　　内脏脂肪素是内脏脂肪合成的脂肪细胞因子，首次发现于2005年[1]。内脏脂肪素具有类胰岛素样作用，参与了多种病理、生理过程。丙型肝炎性肝硬化是丙型肝炎终末期临床表现，该病亦属于代谢性疾病，内脏脂肪素与肝病的发生、发展关系密切。本研究对117例丙型肝炎性肝