重症中暑患者血浆中的β2-微球蛋白和E-选择素的变化.docVIP

精品论文 参考文献 重症中暑患者血浆中的β2-微球蛋白和E-选择素的变化 复旦大学附属中山医院青浦分院EICU 上海 201700 【摘 要】目的：探求重症中暑患者血浆中的beta;2-微球蛋白和E-选择素的变化及其对预后的关系。 方法：对象为2013年5月至2014年9月收入我院EICU16例重症中暑患者，留取入院后24小时内血样本，采用我院健康体检残血样本20例为对照组，运用APACHEⅡ评分评估疾病危重程度，ELISA法检测血浆中beta;2-微球蛋白和E-选择素的质量浓度。结果：16例患者中，痊愈10例（62.5%），死亡6例（37.5%）；对照组的beta;2-微球蛋白和E-选择素的质量浓度分别为0.129plusmn;0.023mg/L和39.12plusmn;4.331ng/ml；重症中暑的beta;2-微球蛋白和E-选择素的质量浓度分别为4.570plusmn;0.843mg/L和189.54plusmn;12.67ng/ml；与对照组二者比较均具有统计学差异（P=0.000）；且与APACHEⅡ评分呈正相关（分别为r=0.688.p=0.000; r=0.843. P=0.000），死亡组的水平明显高于存活组（p=0.012.p=0.000）。结论：在重症中暑患者血浆中的beta;2-微球蛋白和E-选择素的变化对于病情危重程度评估和预后有密切相关，必要时可以作为预后判定的参考。 【关键词】重症中暑；E-选择素；beta;2-微球蛋白 【中图分类号】R595.4 【文献标识码】A 【文章编号】1764-8999（2015）7-0796-02 The change of beta;2-microglobulin and E-selectin in the heat shock ZHANG Mei-yuan,TANG-yan. Emergency Intensive Care Unit, Qingpu Branch of Zhongshan Hospital, FuDan Vniversity, Shanghai 201700 【Abstract】Objective：To study the change of of beta;2-microglobulin and E-selectin in the heat shock, and analyze the relationship with the prognosis of diseases. Methods：For prospective study, 16 heat illnesses admitted in emergency intensive care unit(EICU) from May, 2013 to September, 2014 as the heat shock group were enrolled, and blood specimens were collected with 24 hours after admission. Another 20 cases blood samples were collected from the healthy personsrsquo; physical examination as the control group. The severity of the heat illnesses were evaluated by Acute Physiology and Chronic Health EvaluationⅡ(APACHE). The levels of serum beta;2-microglobulin and E-selectin were measured by double antibody sandwich enzyme-linked immunoassay (ELISA). Results：In 16 patients, 10 cases were cured (62.5%) and 6 cases died (37.5%). E-selectin and beta;2-microglobulin in the control group and the heat shocks were (0.129plusmn;0.023)mg/L,(39.12plusmn;4.331)ng/ml, and (4.570plusmn;0.843)mg/L, (189.54plusmn;12.67) ng/ml, respectively, there were statistical differences between two g