胱抑素C测定在肾功能不全中的临床应用.docVIP

精品论文 参考文献 胱抑素C测定在肾功能不全中的临床应用 张兴宗 林云 张红文 文晓燕（云南省中医医院检验科 云南昆明 650021） 【中图分类号】R446【文献标识码】A【文章编号】1672-5085（2012）9-0063-02 【摘要】目的 探讨肾功能损害时血清胱抑素C(Cystatin C,CysC)作为早期敏感标志物对临床诊断的价值。方法　采用胶乳增强透射比浊法测定血清CysC的浓度,同时测定血肌酐(Scr)、尿素（BUN）与肾小球滤过率（GFR）进行比较。结果　血清CysC在健康对照组、肾功能不全代偿期组、肾功能不全失代偿期组、肾衰竭组、尿毒症期组测定值分别为(0.83plusmn;0.28)、(1.44plusmn;0.33)、(2.31plusmn;0.61)、(5.09plusmn;1.68)、(7.93plusmn;1.25)mg/L,随着肾功能的损害程度增加,血清CysC的浓度升高,相邻各组之间CysC差异均有统计学意义(Plt;0.01)。肾功能不全代偿期组血清CysC值与健康对照组相比差异有统计学意义(Plt;0.05),而两组Scr、NUB相比差异无统计学意义(Pgt;0.05)。结论 肾功能不全不同损害期血清Cys C浓度与肾功能损害程度相关，血清CysC作为反映肾脏损伤的敏感指标,在肾功能损害早期优于Scr、BUN，Cys C与其他肾功能指标联合检测对正确评估肾功能损害程度有重要临床价值。 【关键词】胱抑素C 肾功能损害 肾小球滤过率 肾衰竭 Clinical chemistry pharmacological basis are not satisfied with the result of the importance of the project analysis Zhang Xing-zong，LinYun，Zhang Hong-wen，WenXiao-yan Department of Clinical Laboratory，Yunnan Provincial Hospital of Traditional Chinese Medicine，Kunming Yunnan 650021，China． 【Abstract】 Objective Explore when renal impairment in serum inhibition change C (Cystatin C，CysC) as early sensitive marker of clinical diagnosis of value. Methods The latex strengthen transmission method to determine the turbidity than the concentration of the serum CysC，at the same time testing (Scr)，serum creatinine urea (BUN) and estimated glomerular filtration rate (GFR) are compared. Results Serum CysC in health control，renal insufficiency of compensatory group，renal insufficiency decompensated period group，kidney failure group，uremia，respectively，in determination of group (0.83 + /-0.28)，(1.44 + /-0.33)，(2.31 + /-0.61)，(5.09 + /-1.68)，(7.93 + /-1.25) mg/L，with renal damage degree increase，the concentration of the serum CysC increases，adjacent CysC differences between groups are statistically significant (P lt; 0.01). Renal insufficiency of serum CysC compensatory group value and health are statistically significant difference in the control group (P lt; 0.05)，and two groups of Scr，NUB difference in was not statistically sig