蚕丝蛋白共聚改性聚乳酸的合成与表征研究.pdfVIP

蚕丝蛋白共聚改性聚乳酸的合成与表征 周壮丽，高勤卫∗，吴国成，寇琴 （南京林业大学化工学院210037 ） 摘要：本研究直接以L-乳酸和蚕丝蛋白（SF）为原料，经熔融/ 固相反应制备蚕丝蛋白/聚乳酸共聚 物（PSFLA ），并采用核磁共振、红外光谱、特性粘数、旋光法、差示扫描量热法、热重分析、扫描 电子显微镜等手段进行系统表征。熔融共聚采用一次性投料L-乳酸生成重均相对分子量达几千的 PLLA 聚乳酸预聚物，然后直接与蚕丝蛋白缩聚。结果表明：在辛酸亚锡/对甲苯磺酸催化体系下聚 乳酸与丝肽可以聚合得到嵌段共聚物。 关键词：L-乳酸；蚕丝蛋白；熔融/ 固相聚合；共聚物 The synthesis and characterization of silk protein copolymerization modification gathering the lactic acid ZHOU Zhuangli ,GAO Qinwei ,WU Guocheng ,KOU Qin (Nanjing Forestry University Chemical industry Institute 210037) Abstract:This research directly take the L- lactic acid and the silk protein (SF) as a raw material, after the fusing/solid phase responded that the preparation silk protein/gathers lactic acid copolymerization the thing (PSFLA), and uses the nuclear magnetic resonance, the infrared spectrum, the limiting viscosity number, the optical activity law, the differential scanning calorimetry, the thermogravimetric analysis, to scan methods and so on electron microscope to carry on the system attribute. The fusing copolymerization uses disposable gets ready the materials the L- lactic acid to produce the heavy relative molecular weight to reach several thousand PLLA to gather the lactic acid prepolymer, then direct and silk protein condensation. The result indicated: /Gathers in the stannous octoate to the toluene sulfonic acid catalysis system under the lactic acid and the silk peptide may get together obtains the block copolymer. Keywords: L- lactic acid; Silk protein; Fusing/solid polymerization; Copolymer 聚乳酸(PLA)是具有生物降解性和生物相容性的高分子材料, 但是随着聚乳酸应用领域的不断 开拓，聚乳酸均聚物已不能满足应用要求，例如：由于欠缺良好的亲水性，聚乳酸的生物相容性还 不很理想，不利于细胞缴附、增殖和分化；在生体环境中，不能完全排除致炎效应；降解速度难以 控制，强度和韧性不够和降解中间产物乳酸在体内形成酸性微环境等不足之处，成为人们普遍关注 和期待解决的前沿问题。为此人们对聚乳酸进行大量的改性研究，如乳酸-乙醇酸共聚物无毒、生物 相容、可在生物体