不同剂量阿托伐他汀对高血压患者颈动脉硬化的影响.docVIP

精品论文 参考文献 不同剂量阿托伐他汀对高血压患者颈动脉硬化的影响 陈子国（福建医科大学附属南平市第一医院心内科 福建南平 353000） 【中图分类号】R544.1【文献标识码】A【文章编号】1672-5085（2011）44-0459-03 【摘要】目的 比较不同剂量阿托伐他汀对高血压患者颈动脉硬化的临床疗效。方法 选择存在有不同程度的颈动脉硬化的高血压患者100例，随机分为2组，每组50例，阿托伐他汀40mg/d组及阿托伐他汀20mg/d组,疗程16周。观察治疗前后颈动脉内膜-中层厚度(IMT)以及胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL-C)和高密度脂蛋白胆固醇 (HDL-C)的变化。结果 阿托伐他汀 20mg及40mg组均能明显减轻颈动脉硬化(Plt;0.05)，且阿托伐他汀40mg组降低TC及LDL更明显(Plt;0.01)，但两组减轻颈动脉硬化无明显差异(P＞0.05)。结论 阿托伐他汀40mg组更有效降低TC及LDL水平, 但没有更有效的减轻颈动脉硬化。 【关键词】阿托伐他汀 高血压 颈动脉硬化 Effect of different dosages of atorvastatin on carotid atherosclerosis in hypertensive patients. Chengziguo（Department of Cardiology, Fujian Medical University Affiliated Nan ping First Hospital, fujian 353000,China） 【Abstract】Objective To compare the clinical effect of two different dosages of atorvastatin on carotid atherosclerosis in hypertensive patients. Methods Total 100 patients with carotid atherosclerosis in hypertensive patients were randomized to 20mg/day (n=50) and 40mg/day(n=50) atorvastatin for 16 weeks。The carotid artery inner-inter mediate thickness (IMT) was examined by the colorDoppler, and the plasma TC、LDL-C and HDL-C levels were measured in these patients before treatment and after treatment for 16 weeks.Results After four months of treatment，the carotid artery IMT obviously decreased in both 20mg/day and 40mg/day atorvastatin group（P＜0.05）, the plasma Tc and LDL levels could be significantly decreased in 40mg/day atorvastatin group (P＜0.01)，but the carotid artery IMT did not significantly decreased in 40mg/day atorvastatin group than 20mg/day atorvastatin group（P＞0.05）. Conclusion The plasma Tc and LDL levels could be significantly decreased in 40mg/day atorvastatin group，but it had no more effective to reduce carotid atherosclerosis. 【Key words】 Atorvastatin Hypertension Carotid atherosclerosis 高血压病与动脉粥样硬化是两种独立的病；但血压升高与动脉粥样硬化的发生发展密切相关,是动脉粥样硬化的高危因素；高血压合并外周血管病变的患者脑卒中的危险性大大增加[1]。因此有效控制高血压病患者动脉硬化发展对于改善高血压病患者的预后,降低心脑血管事件的发生率具有重要意义。在本试验中,我们对高血压颈动脉患者给予不同剂量阿托伐他汀治疗 ,并运用多普勒彩超检查对治疗