川东北地区抗结核药物性肝损害的临床分析.docVIP

精品论文 参考文献 川东北地区抗结核药物性肝损害的临床分析 郝伟迤 苏 强 杨思芸通讯作者 王龙飞 唐 捷 　　南充市中心医院，川北医学院附属第二临床医学院 四川南充 637000 　　【摘 要】目的：调查分析抗结核药物诱导肝损害的危险因素及临床特点。方法：回顾性调查分析 2010 年 8月至 2014 年 9月在川东北地区4家三甲医院进行抗结核治疗患者的肝功能情况。结果：符合本次调查标准的患者共4272例，其中412例发生肝损害，发生率9.5%；老年患者肝损害发生率为20.8%（20/96）明显高于非老年患者9.3%（390/4176），差异有统计学意义（chi;2=14.28，P＜0.01）；412例肝损害患者中，318例（77.2%）发生于用药60d 内；300例（72.8%）患者出现典型肝炎临床症状，112例患者无症状（27.2%）；经治疗 387 例（93.9%）患者痊愈或好转，25例（6.1%）患者未愈。结论：老年患者中抗结核药物性肝损害发生率高，对其应注意预防，早期诊断和及时合理的治疗。 　　【关键词】抗结核药物；肝损害；临床分析 　　【中图分类号】R825 【文献标识码】B 【文章编号】1674-8999（2015）8-0210-02 　　Clinical analysis of the antituberculosis drug induced liver injury in North Sichuan 　　Hao Wei Yi,Su Qiang,Yang Si Yun,Wang Long Fei,Tang Jie 　　(Nanchong Central Hospital,The Second Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan China) 　　【Abstract】Objective To analyze the risk factors associated and the clinical characteristics of liver injury induced by antituberculosis drug. Method：The tuberculosis patients treated in North Sichuan hospital during the period from August 2010 to September 2014 were collected and analyzed of the prevalence of liver injury induced by antituberculosis drug.Result：4272 cases were collected in the survey and there were 412 cases 9.5％ who were demonstrated antituberculosis drug-induced liver injury.The hepatic lesion incidence in Old patients liver injury case was 20.8%（20/96）was significantly higher than that of 9.3%（390/4176）of young adults patients. 318 patients developed the reaction within 60 days accounting for 77.2%. 300（72.8%）emerged related hepatitis symptoms, 112 patients（27.2%）were all asymptomatic and only found abnormalities in liver function examination.387 （93.9%）experienced normalization or markedly improved of the liver function and 25（6.1%）showed poor effects.Conclusions：antituberculosis induced hepatic lesions might easily occur to old patients. Its prevention ,early diagnosis and proper treatment were of utmost importance and should be emphasized.