川西地区妇女hpv亚型与宫颈病变的关系.docVIP

精品论文 参考文献 川西地区妇女HPV亚型与宫颈病变的关系 雅安市人民医院妇产科 625000 【作者简介】刘成红，女，1973年9月12日，羌族，妇产科副主任医师，硕士研究生，雅安市人民医院妇产科，妇科肿瘤，雅安市雨城区大南街18号，625000 课题编号2010--S1030304 项目名称：川西地区妇女HPV感染与宫颈癌关系的研究 【摘要】目的：研究川西地区妇女HPV亚型与宫颈病变的关系。方法：对川西地区2000例有性生活史妇女进行宫颈癌HPV筛查，将其中HPV阳性且宫颈外观不光滑或肥大、质硬以及年龄30岁以上宫颈外观光滑者行阴道镜下宫颈活检。并将HPV亚型类型与其宫颈病理检查结果相结合分析。结果：宫颈CINII及以上病变组中，HPV-18型比例最高，占55%，HPV-16型和HPV-非16/18型分别占21.67%和23.33%；在宫颈CINI及炎性病变组中，HPV-非16/18型占83.33%,HPV-18型占16.67%。结论：HPV-18型和HPV-16型是宫颈病变的高危因素，且HPV-18是高级别宫颈病变中最常见的HPV亚型，可作为重点监测。 【关键词】川西地区；HPV亚型；宫颈病变 Relationship of women HPV subtypes and cervical lesions in the Western of Si Chuan 【Abstract】Objective: To study the relationship between the Western of Si Chuan of women with HPV subtypes and cervical lesions. Methods: Screening out cervical HPV from the western 2000 cases of women with sexual life history, of which were positive-HPV patients with cervical appearing rough or firm and hypertrophy would be underwent colposcopy cervical biopsy, also including the crowd of 30 years or older with smooth cervical. Then we would classify the biopsy results into five groups: invasive carcinoma, CINIII, CINII, CINI, chronic inflammation. Combining the subtypes of HPV and cervical pathological findings together in search of some relevance between specific subtypes of the western population with high-risk HPV infection. Results: chronic inflammation group, none of HPV-16 type, 2 cases of HPV-18 type and 8 cases of non-HPV- 16/18. In the CINII cervical lesions and above group, HPV-18 type would be the highest proportion of 55%, HPV-16 and non -HPV- 16/18 type accounted for 21.67% and 23.33%, respectively; non-HPV-16/18 type accounted for 83.33%, HPV-18 type was about 16.67%, in the rest groups. Conclusion: HPV-18 and HPV-16 type are high-risk factors of cervical lesions and HPV-18 is the most common HPV subtypes in high-grade cervical lesions, which can be used as main monitoring. 【Key words】 Western of Si Chuan; HPV subtypes; cervical lesions 宫颈癌在女性恶性肿瘤中的发病率和死亡率