abo新生儿溶血病实验室检测结果的相关分析.docVIP

精品论文 参考文献 ABO新生儿溶血病实验室检测结果的相关分析 陈晓曼 薛小萍（通讯作者） 　　（江苏省苏北人民医院临床输血科 江苏扬州 225001） 　　【摘要】目的：通过分析2014年7月至2015年6月送检的261例新生儿溶血病筛查标本的实验室检测结果，探讨发生ABO新生儿溶血病( hemolytic disease of the newborn ，HDN)的血型模式，溶血三项试验之间阳性率的差异，以及追溯孕妇产前IgG血型抗体效价来分析其与ABO-HDN发病的相关性。方法：均采用微柱凝胶法。结果：261例送检标本ABO-HDN的发病率为26.8%（70例），以A型较多;70例ABO-HDN溶血三项试验中红细胞抗体释放试验阳性率最高;70例ABO-HDN中，孕妇产前IgG抗体效价越高所占有的比率越大。结论：及早进行相关实验室相关检测，及早对患儿治疗对阻止溶血的进一步发生极为重要。 　　【关键词】新生儿溶血病；溶血三项试验；IgG抗体效价； 　　【中图分类号】R446 【文献标识码】A 【文章编号】1007-8231（2015）20-0101-03 　　Laboratory tests of related analysis ABO newborns hemolytic disease. Chen Xiaoman Xue Xiaoping. Clinical Blood Transfusion Department of Subei Peoples Hospital ,Yangzhou, Jiangsu province, 225001,China 　　【Abstract】Objective Through the analysis in July 2014 to June 2015 were 261 cases of neonatal hemolysis disease screening specimen of laboratory testing results, and discussion in ABO newborns hemolytic disease (hemolytic diseases of the newborn, HDN) blood type model, the difference of positive rate between three hemolysis test, blood type and traces the prenatal IgG antibody titer to analyze its correlation with ABO HDN - come on. Method Adopted micro column gel method . Results The incidence of 261 cases of samples ABO HDN - 26.8% (70 cases), to model A more . In 70 cases of ABO HDN - three hemolysis test ,erythrocyte antibody release test positive rate highest; Of 70 patients ABO - HDN, the higher the prenatal IgG antibody titer possession ratio is larger. Conclusion Related laboratory tests as early as possible, as soon as possible for children is very important to prevent hemolysis further treatment. . 　　【Key words】Hemolytic disease of the newborn; Three hemolysis test ; IgG antibody titer 　　新生儿溶血病（HDN）常发生于胎儿期及新生儿早期[1]，主要原因为母???血型不合，孕母体内IgG类血型抗体通过胎盘进入胎儿体内，胎儿红细胞被母亲的同种抗体包被，这种抗体是针对胎儿红细胞上父源性的抗原，被包被的红细胞在分娩前后加速破坏，造成胎儿发生以溶血为主要损害的一种被动免疫性疾病，可发生严重的神经系统后遗症。HDN又以ABO血型不合引起的溶血病（ABO-HDN）为多见，据研究报道得，将孕妇的产前检查和新生儿溶血三项试验结合起来进行风险评估以及相应治疗能有效降低新生儿溶血病的发病风险[1]。现笔者