2 型糖尿病患者高尿酸血症与冠心病的关系.docVIP

精品论文 参考文献 2 型糖尿病患者高尿酸血症与冠心病的关系 1南华大学附属第二医院内分泌科 湖南衡阳 421001；2南华大学附属第二医院重症医学科 湖南衡阳 421001 【摘 要】目的探讨2型糖尿病患者高尿酸血症与冠心病的关系。方法收集2013年1月至2015年12月在我科住院治疗的2型糖尿病患者200例，根据UA水平分为高尿酸血症组（HUA）和正常尿酸组（NUA）。比较两组血（CH、TG、HDL），血糖（BS），血尿酸（uA），尿素氮（BUN）检测结果，做单因素Logistic回归。结果200例50岁以上患者的尿酸水平有60％ 增高，显著高于同年龄健康人群。高血尿酸组血脂，血糖，血尿酸，尿素氮结果明显高于血尿酸正常组，尤其是甘油三酯（TG）和血尿酸结果（Plt;0．001），有显著性差异。按照alpha;=0．20检验水准，糖尿病病程、高血压史、TCH、LDL-C、尿酸有统计学意义，其他变量对是否患冠心病的影响无统计学意义。结论 高尿酸血症会显著增加2型搪尿病患者冠心病的发病风险，在临床工作中，医师应提高对高尿酸血症危险性的认识，积极给予治疗。 【关键词】高尿酸血症；2型糖尿病；冠心病 [Abstract]Objective To investigate the relationship between hyperuricemia and coronary heart disease in patients with type 2 diabetes mellitus.Methods from January 2013 to December 2015，2 patients with type 200 diabetes who were hospitalized in our department were divided into hyperuricemia group（HUA）and normal uric acid group（NUA）according to the level of UA.Comparison of two groups of blood（CH，TG，HDL），blood glucose（BS），serum uric acid（uA），urea nitrogen（BUN）test results，do a single factor Logistic regression.Results 200 patients over 50 years old，there are 60% levels of uric acid increased，significantly higher than that of healthy people the same age.High blood uric acid group blood lipid，blood glucose，blood uric acid，blood urea nitrogen were significantly higher than that in normal uric acid group，especially triglycerides（TG）and the serum uric acid（Plt;0.001），there was significant difference.According to a =0.20 standard test，there was statistical significance of diabetes，hypertension，TCH，LDL-C，uric acid，other variables had no significant effect on whether the risk of coronary heart disease.Conclusion hyperuricemia will significantly increase the risk of type 2 diabetic patients with coronary heart disease，in clinical work，physicians should raise awareness of risk of hyperuricemia，given the active treatment. [keyword]：hyperuricemia；type 2 diabetes；coronary heart disease 我国的代谢综合征患病率已经高达14％～18％[1]。高尿酸血症与代谢综合密切相关，其患病率也在迅速地上升。随着我国人民生活水平的提高，高尿酸血症的患病率也已超过10