后期促进因子(apc7)在人大肠癌预后表达的研究late promoting factor (apc7) expressed in npc prognosis of colorectal cancer research.pdfVIP
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后期促进因子(apc7)在人大肠癌预后表达的研究late promoting factor (apc7) expressed in npc prognosis of colorectal cancer research
延边大学瞰学滞基灿k学院彤川.沦文 isa Anaphase-promotingComplex(APC)7 Prognostic FactorinHumanColorectal Cancer Abstract Objeetive:Theanaphase the promoting of mitotic aswellasothersubstratesinvolvedin degradation cyclins sisterchromatidadhesion.Thiswas study carriedouttoexaminethe betweentheAPC and the relationship expression all todeterminetheroleoftheAPCinthecolorectal variables,in attempt cancerandtoevaluatethe an of aberrantAPCfunctionin possibility resectedadenocarcinomaofcolorectum. surgically Methods: Immunohistochemicalwas forAPCAndKi一67in103 stainingperformed casesofAdenocarcinomaandl l casesof mucinousadenocacarinomaof the method.Results:Incolon colorectum,using avidin—biotin—peroxidase 44 reactionsforAPC. cancer,thecases(67.7%)showed immunopositive The APC in 3were16 posivityhistologicgrades1,2,and cases(36.3%), 15 13 therectal cases(34%),andcases(29.7%),respectively.Incancer, the38 reactionsfor cases(77.6%)showed APC.The
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