有哪些信誉好的足球投注网站detailed mitochondrial phenotyping by high resolution metabolomics详细的线粒体表现型由高分辨率的代谢组学.pdfVIP
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detailed mitochondrial phenotyping by high resolution metabolomics详细的线粒体表现型由高分辨率的代谢组学
Detailed Mitochondrial Phenotyping by High Resolution Metabolomics 1 1 2 3 1 James R. Roede , Youngja Park , Shuzhao Li , Frederick H. Strobel , Dean P. Jones * 1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America, 2 Emory Vaccine Center, Yerkes National Primate Center, Emory University, Atlanta, Georgia, United States of America, 3 Mass Spectrometry Center, Emory University, Atlanta, Georgia, United States of America Abstract Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used ‘‘top- down’’ metabolic profiling to determine the spectrum of metabolites present in liver mitochondria. High resolution mass spectral analyses and multivariate statistical tests provided global metabolic information about mitochondria and showed that liver mitochondria possess a significant phenotype based on gender and genotype. The data also show that mitochondria contain a large number of unidentified chemicals. Citation: Roede JR, Park Y, Li S, Strobel FH, Jones DP (2012) Detailed Mitochondrial Phenotyping by High Resolution Metabolomics. PLoS ONE 7(3): e33020. doi:10.1371/journal.pone.0033020 Editor: Tobias Eckle, University of Colorado Denver, United States of America Received January 30, 2012; Accepted February 4, 2012; Published March 6, 2012 Copyright: 2012 Roede et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and re
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