有哪些信誉好的足球投注网站detailed regulatory mechanism of the interaction between zo-1 pdz2 and connexin43 revealed by md simulations详细的监管机制之间的交互zo-1 pdz2 connexin43透露,md模拟.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
detailed regulatory mechanism of the interaction between zo-1 pdz2 and connexin43 revealed by md simulations详细的监管机制之间的交互zo-1 pdz2 connexin43透露,md模拟
Detailed Regulatory Mechanism of the Interaction between ZO-1 PDZ2 and Connexin43 Revealed by MD Simulations 1 2 1 1,2 Fei Xiao , Jingwei Weng , Kangnian Fan , Wenning Wang * 1 Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, People’s Republic of China, 2 Institute of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China Abstract The gap junction protein connexin43 (Cx43) binds to the second PDZ domain of Zonula occludens-1 (ZO-1) through its C- terminal tail, mediating the regulation of gap junction plaque size and dynamics. Biochemical study demonstrated that the very C-terminal 12 residues of Cx43 are necessary and sufficient for ZO-1 PDZ2 binding and phosphorylation at residues Ser (-9) and Ser (-10) of the peptide can disrupt the association. However, only a crystal structure of ZO-1 PDZ2 in complex with a shorter 9 aa peptide of connexin43 was solved experimentally. Here, the interactions between ZO-1 PDZ2 and the short, long and phosphorylated Cx43 peptides were studied using molecular dynamics (MD) simulations and free energy calculation. The short peptide bound to PDZ2 exhibits large structural variations, while the extension of three upstream residues stabilizes the peptide conformation and enhanced the interaction. Phosphorylation at Ser(-9) significantly weakens the binding and results in conformational flexibility of the peptide. Glu210 of ZO-1 PDZ2 was found to be a key regulatory point in Cx43 binding and phosphorylation induced dissociation. Citation: Xiao F, Weng J, Fan K, Wang W (2011) Detailed Regulatory Mechanism of the Interaction between ZO-1 PDZ2 and Connexin43 Revealed by MD Simulation
您可能关注的文档
- degradation of internalized αvβ5 integrin is controlled by upar bound upa effect on β1 integrin activity and α-sma stress fiber assembly退化内化αvβ5整合素是由upar绑定upa影响β1整合素活动和α-sma应力纤维组装.pdf
- degradation of metalaxyl and mefenoxam and effects on the microbiological properties of tropical and temperate soils甲霜灵和mefenoxam退化对热带和温带土壤的微生物特性的影响.pdf
- degradation of microcystin-lr and rr by a stenotrophomonas sp. strain ems isolated from lake taihu, china美国退化和rr stenotrophomonas sp。应变ems隔绝太湖湖,中国.pdf
- degradation of glyphosate in soil photocatalyzed by fe3o4sio2tio2 under solar light草甘膦在土壤退化photocatalyzed由fe3o4sio2tio2太阳能灯.pdf
- degradation of phosphorylated p53 by viral protein-ecs e3 ligase complex磷酸化p53的病毒protein-ecs e3连接酶降解复杂.pdf
- degradation of rural and urban great tit song testing transmission efficiency退化的农村和城市大山雀歌测试传输效率.pdf
- degradation of psbo by the deg protease hhoa is thioredoxin dependent度蛋白酶hhoa psbo退化的硫氧还蛋白相关的.pdf
- degradation of the disease-associated prion protein by a serine protease from lichens退化疾病有关的朊蛋白的地衣的丝氨酸蛋白酶.pdf
- dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of aktgsk-3β and mtor signaling pathwaysdehydrocostuslactone体外和体内通过抑制血管生成抑制aktgsk-3βmtor信号通路.pdf
- deinococcus geothermalis the pool of extreme radiation resistance genes shrinks耐放射geothermalis极端的辐射抗性基因的范围也在缩小.pdf
- detailed transcriptome description of the neglected cestode taenia multiceps详细的转录组的描述被忽视的绦虫绦虫曲草.pdf
- designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo设计nanoconjugates有效目标胰腺癌细胞在体外和体内.pdf
- detecting cancer gene networks characterized by recurrent genomic alterations in a population检测癌症基因网络的特点是周期性人口基因改变.pdf
- detailed structural analysis of lipids directly on tissue specimens using a maldi-spiraltof-reflectron tof mass spectrometer直接的详细结构分析脂质组织标本使用maldi-spiraltof-reflectron tof质谱计.pdf
- detecting instability in animal social networks genetic fragmentation is associated with social instability in rhesus macaques社交网络检测不稳定在动物遗传分化与社会不稳定在恒河猴.pdf
- destabilization of the dystrophin-glycoprotein complex without functional deficits in α-dystrobrevin null muscle扰动α-dystrobrevin dystrophin-glycoprotein复杂没有功能缺陷的零肌肉.pdf
- detecting regulatory mechanisms in endocrine time series measurements在内分泌时间序列测量检测监管机制.pdf
- detecting low frequent loss-of-function alleles in genome wide association studies with red hair color as example检测低频繁功能丧失的等位基因的全基因组研究协会红头发的颜色为例.pdf
- detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy检测血液中改变转录组存在公开经过两个星期的治疗.pdf
- detection and characterization of wolbachia infections in natural populations of aphids is the hidden diversity fully unraveled沃尔巴克氏体属感染的检测和表征自然种群的蚜虫是隐藏的多样性完全瓦解.pdf
文档评论（0）