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deregulation of rab and rab effector genes in bladder cancerrab和rab管制的效应基因在膀胱癌
Deregulation of Rab and Rab Effector Genes in Bladder Cancer 1,2 1,2 3 1,2,4 5,6 Joel R. Ho , Elodie Chapeaublanc , Lisa Kirkwood , Remy Nicolle , Simone Benhamou , 7 8,9 3 1,2 1,2 Thierry Lebret , Yves Allory , Jennifer Southgate , Franc¸ois Radvanyi , Bruno Goud * 1 Institut Curie, Centre de Recherche, Paris, France, 2 CNRS, UMR 144, Paris, France, 3 Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of ´ ´ York, York, United Kingdom, 4 Universite d’Evry, iSSB, Evry, France, 5 CNRS, UMR 8200, Institut de Cancerologie Gustave Roussy, Villejuif, France, 6 INSERM, U946, Paris, ´ ˆ ´ France, 7 Departement d’Urologie, Hopital Foch, Suresnes, France, 8 AP-HP, Groupe Hospitalier Henri Mondor, Plateforme de Ressources Biologiques, Departement de ´ ´ ´ Pathologie, Creteil, France, 9 INSERM, Unite 955, Creteil, France Abstract Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in eukaryotic cells, play an important role in cancer. We analysed the deregulation at the transcriptional level of the genes encoding Rab proteins and Rab- interacting proteins in bladder cancer pathogenesis, distinguishing between the two main progression pathways so fa
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