有哪些信誉好的足球投注网站defining hypo-methylated regions of stem cell-specific promoters in human ips cells derived from extra-embryonic amnions and lung fibroblasts定义hypo-methylated特异性启动子区域的茎在人类u201c诱导多能性u201d细胞来源于胚外羊膜和肺成纤维细胞.pdfVIP
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defining hypo-methylated regions of stem cell-specific promoters in human ips cells derived from extra-embryonic amnions and lung fibroblasts定义hypo-methylated特异性启动子区域的茎在人类u201c诱导多能性u201d细胞来源于胚外羊膜和肺成纤维细胞
Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra- Embryonic Amnions and Lung Fibroblasts 1 1 1 1 1 Koichiro Nishino , Masashi Toyoda , Mayu Yamazaki-Inoue , Hatsune Makino , Yoshihiro Fukawatase , 1 1 2 2 2 Emi Chikazawa , Yoriko Takahashi , Yoshitaka Miyagawa , Hajime Okita , Nobutaka Kiyokawa , 1 1 Hidenori Akutsu , Akihiro Umezawa * 1 Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan, 2 Department of Developmental Biology, National Institute for Child Health and Development, Tokyo, Japan Abstract Background: Human induced pluripotent stem (iPS) cells are currently used as powerful resources in regenerative medicine. During very early developmental stages, DNA methylation decreases to an overall low level at the blastocyst stage, from which embryonic stem cells are derived.Therefore, pluripotent stem cells, such as ES and iPS cells, are considered to have hypo-methylated status compared to differentiated cells. However, epigenetic mechanisms of ‘‘stemness’’ remain unknown in iPS cells derived from extra-embryonic and embryonic cells. Methodology/Principal Findings: We examined genome-wide DNA methylation (24,949 CpG sites covering 1,3862 genes, mostly selected from promoter regions) with six human iPS cell lines derived from human amniotic cells and fetal lung fibroblasts as well as two human ES cell lines, and eight human differentiated cell lines using Illumina’s Infinium HumanMethylation27. A co
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