有哪些信誉好的足球投注网站depot-dependent effects of adipose tissue explants on co-cultured hepatocytesdepot-dependent脂肪组织外植体对培养肝细胞的影响.pdfVIP
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depot-dependent effects of adipose tissue explants on co-cultured hepatocytesdepot-dependent脂肪组织外植体对培养肝细胞的影响
Depot-Dependent Effects of Adipose Tissue Explants on Co-Cultured Hepatocytes 1 2 1 2 2 1 1,2 Zhen-Yu Du *, Tao Ma , Erik-Jan Lock , Qin Hao , Karsten Kristiansen , Livar Frøyland , Lise Madsen 1 National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway, 2 Department of Biology, University of Copenhagen, Copenhagen, Denmark Abstract We have developed an in vitro hepatocyte-adipose tissue explant (ATE) co-culture model enabling examination of the effect of visceral and subcutaneous adipose tissues on primary rat hepatocytes. Initial analyses of inflammatory marker genes were performed in fractionated epididymal or inguinal adipose tissues. Expressions of inflammation related genes (IL-6, TNF-a, COX-2) were higher in the inguinal than the epididymal ATE. Similarly, expressions of marker genes of macrophage and monocyte (MPEG-1, CD68, F4/80, CD64) were higher in the stromal vascular fraction (SVF) isolated from inguinal ATE than that from epididymal ATE. However, expressions of lipolysis related genes (ATGL, HSL, perilipin-1) were higher in the epididymal adipocytes than inguinal adipocytes. Moreover, secretion of IL-6 and PGE2 was higher from inguinal ATEs than from epididymal ATEs. There was a trend that the total levels of IL-6, TNF-a and PGE2 in the media from inguinal ATEs co- cultured with primary rat hepatocytes were higher than that in the media from epididymal ATEs co-cultured with hepatocytes, although the significant difference was only seen in PGE2. Lipolysis, measured as glycerol release, was similar in the ATEs isolated from inguinal and epididymal adipose tissues when cultured alone, but the glycerol release was higher in the ATEs isolated
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