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derivation of high purity neuronal progenitors from human embryonic stem cells推导的高纯度从人类胚胎干细胞神经祖细胞
Derivation of High Purity Neuronal Progenitors from Human Embryonic Stem Cells 1 2 3 1 2 Gabriel Nistor , Monica M. Siegenthaler , Stephane N. Poirier , Sharyn Rossi , Aleksandra J. Poole , 3 3 2 1 Maura E. Charlton , John D. McNeish , Chris N. Airriess , Hans S. Keirstead * 1 Reeve-Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy and Neurobiology, School of Medicine, Sue Bill Gross Hall, a CIRM Institute, University of California Irvine, Irvine, California, United States of America, 2 California Stem Cell, Inc., Irvine, California, United States of America, 3 Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America Abstract The availability of human neuronal progenitors (hNPs) in high purity would greatly facilitate neuronal drug discovery and developmental studies, as well as cell replacement strategies for neurodegenerative diseases and conditions, such as spinal cord injury, stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. Here we describe for the first time a method for producing hNPs in large quantity and high purity from human embryonic stem cells (hESCs) in feeder-free conditions, without the use of exogenous noggin, sonic hedgehog or analogs, rendering the process clinically compliant. The resulting population displays characteristic neuronal-specific markers. When allowed to spontaneously differentiate into neuronal subtypes in vitro, cholinergic, serotonergic, dopaminergic and/or noradrenergic, and medium spiny striatal neurons were o
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