有哪些信誉好的足球投注网站deregulated sex chromosome gene expression with male germ cell-specific loss of dicer1管制性染色体基因表达与男性生殖特异性dicer1的损失.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
deregulated sex chromosome gene expression with male germ cell-specific loss of dicer1管制性染色体基因表达与男性生殖特异性dicer1的损失
Deregulated Sex Chromosome Gene Expression with Male Germ Cell-Specific Loss of Dicer1 1 . 1.¤ 1 1 1 Anne R. Greenlee * , Meng-Shin Shiao , Elizabeth Snyder , F. William Buaas , Tongjun Gu , 1 1 2 3 1 Timothy M. Stearns , Manju Sharma , Elizabeth P. Murchison , Gabriella C. Puente , Robert E. Braun 1The Jackson Laboratory, Bar Harbor, Maine, United States of America, 2 Wellcome Trust Sanger Institute, Hinxton, United Kingdom, 3 Yale University, New Haven, Connecticut, United States of America Abstract MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs that mediate post-transcriptional gene silencing by inhibiting mRNA translation and promoting mRNA decay. DICER1, an RNase III endonuclease encoded by Dicer1, is required for processing short 21–22 nucleotide miRNAs from longer double-stranded RNA precursors. Here, we investigate the loss of Dicer1 in mouse postnatal male germ cells to determine how disruptions in the miRNA biogenesis pathway may contribute to infertility. Reduced levels of Dicer1 transcripts and DICER1 were confirmed in germ cell knock-out (GCKO) testes by postnatal day 18 (P18). Compared to wild-type (WT) at 8 weeks, GCKO males had no change in body weight; yet showed significant reductions in testis mass and sperm number. Histology and fertility tests confirmed spermatogenic failure in GCKO males. Array analyses at P18 showed that in comparison to WT testes, 75% of miRNA genes and 37% of protein coding genes were differentially expressed in GCKO testes. Among these, 96% of
您可能关注的文档
- degradability of polymers for implantable biomedical devices降解性的聚合物植入式生物医学设备.pdf
- deformed density matrix and quantum entropy of the black hole畸形的密度矩阵和量子黑洞的熵.pdf
- defining hypo-methylated regions of stem cell-specific promoters in human ips cells derived from extra-embryonic amnions and lung fibroblasts定义hypo-methylated特异性启动子区域的茎在人类u201c诱导多能性u201d细胞来源于胚外羊膜和肺成纤维细胞.pdf
- degradation characteristics of wood using supercritical alcohols使用超临界醇降解木材的特点.pdf
- degradation mechanisms for gan and gaas high speed transistors氮化镓和砷化镓高速晶体管退化机制.pdf
- deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure赤字在水迷宫性能和氧化应激引起的海马和纹状体极低频磁场暴露.pdf
- deficiency of a niemann-pick, type c1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity缺乏一种尼曼,c1-related蛋白质在弓形虫与多个重要性和致病性的增加有关.pdf
- degradation of internalized αvβ5 integrin is controlled by upar bound upa effect on β1 integrin activity and α-sma stress fiber assembly退化内化αvβ5整合素是由upar绑定upa影响β1整合素活动和α-sma应力纤维组装.pdf
- degradation of metalaxyl and mefenoxam and effects on the microbiological properties of tropical and temperate soils甲霜灵和mefenoxam退化对热带和温带土壤的微生物特性的影响.pdf
- degradation of microcystin-lr and rr by a stenotrophomonas sp. strain ems isolated from lake taihu, china美国退化和rr stenotrophomonas sp。应变ems隔绝太湖湖,中国.pdf
- deregulation of creb signaling pathway induced by chronic hyperglycemia downregulates neurod transcription放松管制的分子信号通路引起的慢性高血糖会使neurod转录.pdf
- derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation推导的骨髓cell-binding腺病毒基因治疗的炎症.pdf
- deposition of metal-organic frameworks by liquid-phase epitaxy the influence of substrate functional group density on film orientation沉积有机框架通过液相外延衬底官能团密度对电影的影响方向.pdf
- derivation of human differential photoreceptor-like cells from the iris by defined combinations of crx, rx and neurod人类微分推导photoreceptor-like细胞从虹膜crx的组合定义,rx和neurod.pdf
- depot-dependent effects of adipose tissue explants on co-cultured hepatocytesdepot-dependent脂肪组织外植体对培养肝细胞的影响.pdf
- derivation of high purity neuronal progenitors from human embryonic stem cells推导的高纯度从人类胚胎干细胞神经祖细胞.pdf
- derivation of xeno-free and gmp-grade human embryonic stem cells – platforms for future clinical applications推导xeno-free和gmp-grade人类胚胎干细胞u2014u2014未来临床应用的平台.pdf
- deriving mechanisms responsible for the lack of correlation between hypoxia and acidity in solid tumors推导机制负责在实体肿瘤缺氧和酸度之间缺乏相关性.pdf
- derlin-1 deficiency is embryonic lethal, derlin-3 deficiency appears normal, and herp deficiency is intolerant to glucose load and ischemia in micederlin-1缺乏是胚胎致死,derlin-3不足出现正常和爬虫缺乏是不能容忍在小鼠葡萄糖负荷和缺血.pdf
- describing and quantifying asthma comorbidty a population study描述和量化哮喘comorbidty人口研究.pdf
文档评论（0）