有哪些信誉好的足球投注网站dendritic cells reveal a broad range of mhc class i epitopes for hiv-1 in persons with suppressed viral load on antiretroviral therapy树突细胞显示广泛的mhc类我为hiv - 1抗原表位在抗逆转录病毒治疗抑制病毒载量的人.pdfVIP
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dendritic cells reveal a broad range of mhc class i epitopes for hiv-1 in persons with suppressed viral load on antiretroviral therapy树突细胞显示广泛的mhc类我为hiv - 1抗原表位在抗逆转录病毒治疗抑制病毒载量的人
Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy 1 1 1 1 2 Xiao-Li Huang , Zheng Fan , LuAnn Borowski , Robbie B. Mailliard , Morgane Rolland , James I. Mullins2, Richard D. Day1,3, Charles R. Rinaldo1,3,4* 1 Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Microbiology, University of Washington, Seattle, Washington, United States of America, 3 Department of Biostatistics, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department of Pathology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Background: HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level replication upon cessation of ART or development of drug resistance. Reactivity of memory CD8+ T lymphocytes to HIV-1 could potentially inhibit this residual viral replication, but is largely muted by ART in relation to suppression of viral antigen burden. Dendritic cells (DC) are important for MHC class I processing and presentation of peptide epitopes to memory CD8+ T cells, and could potentially be targeted to activate memory CD8+ T cells to a broad array of HIV-1 epitopes during ART. Principal Findings: We show for the first time that HIV-1 peptide-loaded, CD40L-matured DC from HIV-1 infected persons on ART induce IFN gamma production by CD8+ T cells specific for a much broader range and magnitude of Gag and
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