default-mode-like network activation in awake rodentsdefault-mode-like网络激活清醒啮齿动物.pdfVIP

Default-Mode-Like Network Activation in Awake Rodents 1 1 1 2 2 3 Jaymin Upadhyay *, Scott J. Baker , Prasant Chandran , Loan Miller , Younglim Lee , Gerard J. Marek , 1 1 1 1 1 Unal Sakoglu , Chih-Liang Chin , Feng Luo , Gerard B. Fox , Mark Day * 1Translational Sciences, Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, United States of America, 2 Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, United States of America, 3 Neuroscience Development, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, United States of America Abstract During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer’s, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess ‘DMN-like’ functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and