有哪些信誉好的足球投注网站defective expression and function of the leukocyte associated ig-like receptor 1 in b lymphocytes from systemic lupus erythematosus patients有缺陷的表达和功能相关的白细胞ig-like受体1 b淋巴细胞从系统性红斑狼疮病人.pdfVIP
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defective expression and function of the leukocyte associated ig-like receptor 1 in b lymphocytes from systemic lupus erythematosus patients有缺陷的表达和功能相关的白细胞ig-like受体1 b淋巴细胞从系统性红斑狼疮病人
Defective Expression and Function of the Leukocyte Associated Ig-like Receptor 1 in B Lymphocytes from Systemic Lupus Erythematosus Patients 1 3,4 1 2 1 Barbara M. Colombo , Paolo Canevali , Ottavia Magnani , Edoardo Rossi , Francesco Puppo , Maria 4 3 Raffaella Zocchi , Alessandro Poggi * 1 Department of Internal Medicine, University of Genoa, Genoa, Italy, 2 Department of Hematology, IRCCS-A.O.U-San Martino-IST-National Institute for Cancer Research, Genoa, Italy, 3 Laboratory of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, IRCCS-Azienso Ospedaliera Universitaria (AOU) San Martino, Genoa, Italy, 4 Division of Immunology, Transplant and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy Abstract Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies and dysregulation of B cell function. The leukocyte associated Immunoglobulin (Ig)-like receptor (LAIR)1 is a transmembrane molecule belonging to Ig superfamily which binds to different types of collagen. Herein, we have determined the expression and function of LAIR1 on B lymphocyte from SLE patients. LAIR1 expression in peripheral blood B lymphocytes from 54 SLE, 24 mixed connective tissue disease (MCTD), 20 systemic sclerosis (SSc) patients, 14 rheumatoid arthritis (RA) and 40 sex and age matched healthy donors (HD) have been analyzed by immunofluorescence. The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph
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