有哪些信誉好的足球投注网站deep-sequencing analysis of the mouse transcriptome response to infection with brucella melitensis strains of differing virulence深度排序的鼠标转录组分析应对感染布鲁氏菌melitensis株不同的毒性.pdfVIP
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deep-sequencing analysis of the mouse transcriptome response to infection with brucella melitensis strains of differing virulence深度排序的鼠标转录组分析应对感染布鲁氏菌melitensis株不同的毒性
Deep-Sequencing Analysis of the Mouse Transcriptome Response to Infection with Brucella melitensis Strains of Differing Virulence 1,2. 1. 1 1 1 1 Fangkun Wang , Sen Hu , Wenxing Liu , Zujian Qiao , Yuzhe Gao , Zhigao Bu * 1 State Key Laboratory of Veterinary Biotechnology and Zoonosis Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, People’s Republic of China, 2 Department of Preventive Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai An, Shandong, People’s Republic of China Abstract Brucella melitensis is an important zoonotic pathogen that causes brucellosis, a disease that affects sheep, cattle and occasionally humans. B. melitensis strain M5-90, a live attenuated vaccine cultured from B. melitensis strain M28, has been used as an effective tool in the control of brucellosis in goats and sheep in China. However, the molecular changes leading to attenuated virulence and pathogenicity in B. melitensis remain poorly understood. In this study we employed the Illumina Genome Analyzer platform to perform genome-wide digital gene expression (DGE) analysis of mouse peritoneal macrophage responses to B. melitensis infection. Many parallel changes in gene expression profiles were observed in M28- and M5-90-infected macrophages, suggesting that they employ similar survival strategies, notably the induction of anti- inflammatory and antiapoptotic factors. Moreover, 1019 differentially expressed macrophage transcripts were identified 4 h after infection with the different B. melitensis strains, and these differential transcripts n
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