有哪些信誉好的足球投注网站dengue virus infection perturbs lipid homeostasis in infected mosquito cells登革热病毒感染扰乱体内脂质稳态受感染蚊子细胞.pdfVIP
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dengue virus infection perturbs lipid homeostasis in infected mosquito cells登革热病毒感染扰乱体内脂质稳态受感染蚊子细胞
Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells 1 1. 2. 3. 2 Rushika Perera , Catherine Riley , Giorgis Isaac , Amber S. Hopf-Jannasch , Ronald J. Moore , 2 4 2 3¤ 1,3 Karl W. Weitz , Ljiljana Pasa-Tolic , Thomas O. Metz , Jiri Adamec , Richard J. Kuhn * 1 Markey Center for Structural Biology, Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, 2 Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America, 3 Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America, 4 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Abstract Dengue virus causes ,50–100 million infections per year and thus is considered one of the most aggressive arthropod- borne human pathogen worldwide. During its replication, dengue virus induces dramatic alterations in the intracellular membranes of infected cells. This phenomenon is observed both in human and vector-derived cells. Using high-resolution mass spectrometry of mosquito cells, we show that this membrane remodeling is directly linked to a unique lipid repertoire induced by dengue virus infection. Specifically, 15% of the metabolites detected were significantly different between DENV infected and uninfected cells while 85% of the metabolites detected were significantly different in isolated replication
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