有哪些信誉好的足球投注网站correlation between protein sequence similarity and crystallization reagents in the biological macromolecule crystallization database相关蛋白质序列之间的相似性和结晶试剂在生物大分子结晶数据库.pdfVIP
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correlation between protein sequence similarity and crystallization reagents in the biological macromolecule crystallization database相关蛋白质序列之间的相似性和结晶试剂在生物大分子结晶数据库
Int. J. Mol. Sci. 2012, 13, 9514-9526; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422–0067 /journal/ijms Article Correlation between Protein Sequence Similarity and Crystallization Reagents in the Biological Macromolecule Crystallization Database Hui-Meng Lu 1,2, Da-Chuan Yin 1,2,*, Yong-Ming Liu 1,2, Wei-Hong Guo 1,2 and Ren-Bin Zhou 1 1 Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, Shaanxi, China; E-Mails: luhuimeng@ (H.-M.L.); auliuym@ (Y.-M.L.); gwh@ (W.-H.G.); zhourenbin@ (R.-B.Z.) 2 Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi’an 710072, Shaanxi, China * Author to whom correspondence should be addressed; E-Mail: yindc@; Tel.: +86-29 Fax: +86-29 Received: 1 June 2012; in revised form: 9 July 2012 / Accepted: 10 July 2012 / Published: 27 July 2012 Abstract: The protein structural entries grew far slower than the sequence entries. This is partly due to the bottleneck in obtaining diffraction quality protein crystals for structural determination using X-ray crystallography. The first step to achieve protein crystallization is to find out suitable chemical reagents. However, it is not an easy task. Exhausting trial and error tests of numerous combinations of different reagents mixed with the protein solution are usual
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