correlation of circulating cd133+ progenitor subclasses with a mild phenotype in duchenne muscular dystrophy patients相关的循环cd133 +祖子类温和的表型在杜氏肌萎缩症患者.pdfVIP

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correlation of circulating cd133+ progenitor subclasses with a mild phenotype in duchenne muscular dystrophy patients相关的循环cd133 +祖子类温和的表型在杜氏肌萎缩症患者.pdf

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correlationofcirculatingcd133progenitorsubclasseswithamildphenotypeinduchennemusculardystrophypatients相关的循环cd133祖子类温和的表型在杜氏肌萎缩症患者

Correlation of Circulating CD133+ Progenitor Subclasses with a Mild Phenotype in Duchenne Muscular Dystrophy Patients 1 1 1 1 2 Chiara Marchesi , Marzia Belicchi , Mirella Meregalli , Andrea Farini , Alessandra Cattaneo , Daniele 1 1 2 3 1 4 Parolini , Manuela Gavina , Laura Porretti , Maria Grazia D’Angelo , Nereo Bresolin , Giulio Cossu , Yvan Torrente1* 1 Stem cell Laboratory, Department of Neurological Science, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Maggiore Policlinico, Centro Dino Ferrari, University of Milan, Milan, Italy, 2 Centro Trasfusionale e di Immunologia dei Trapianti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Maggiore Policlinico, University of Milan, Milan, Italy, 3 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) E. Medea, La Nostra Famiglia, Bosisio Parini, Italy, 4 Stem Cell Research Institute, San Raffaele Hospital, Milan, Italy Abstract Background: Various prognostic serum and cellular markers have been identified for many diseases, such as cardiovascular diseases and tumor pathologies. Here we assessed whether the levels of certain stem cells may predict the progression of Duchenne muscular dystrophy (DMD). Methods and Findings: The levels of several subpopulations of circulating stem cells expressing the CD133 antigen were determined by flow cytometry in 70 DMD patients. The correlation between the levels and clinical status was assessed by statistical analysis. The median (6SD) age of the population was 10.6663.81 (range 3 to 20 years). The levels of CD133+CXCR4+CD3