computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent计算机断层扫描成像原发性肺癌小鼠使用liposomal-iodinated对比剂.pdfVIP

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computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent计算机断层扫描成像原发性肺癌小鼠使用liposomal-iodinated对比剂.pdf

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computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent计算机断层扫描成像原发性肺癌小鼠使用liposomal-iodinated对比剂

Computed Tomography Imaging of Primary Lung Cancer in Mice Using a Liposomal-Iodinated Contrast Agent 1 2 3,4 1 5 Cristian T. Badea *, Khannan K. Athreya , Gabriela Espinosa , Darin Clark , A. Paiman Ghafoori , 5 5,6 1 3 3 Yifan Li , David G. Kirsch , G. Allan Johnson , Ananth Annapragada , Ketan B. Ghaghada * 1 Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States of America, 2 University of Texas Medical School at Houston, The University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America, 3 The Edward B. Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, Texas, United States of America, 4 School of Biomedical Informatics, The University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America, 5 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America, 6 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America Abstract Purpose: To investigate the utility of a liposomal-iodinated nanoparticle contrast agent and computed tomography (CT) imaging for characterization of primary nodules in genetically engineered mouse models of non-small cell lung cancer. Methods: Primary lung cancers with mutations in K-ras alone (KrasLA1) or in combination with p53 (LSL-KrasG12D;p53FL/FL) were generated. A liposomal-iodine contrast agent containing 120 mg Iodine/mL was administered systemically at a dose of 16 ml/gm body weight. Longitudinal