computational study of ph-sensitive hydrogel-based microfluidic flow controllers计算研究ph-sensitive hydrogel-based微流体流控制器.pdfVIP

J. Funct. Biomater. 2011, 2, 195-212; doi:10.3390/jfb2030195 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb Article Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers Jundika C. Kurnia , Erik Birgersson and Arun S. Mujumdar Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore; E-Mail: jc.kurnia@.sg Department of Chemical and Bio-Molecular Engineering, National University of Singapore, 5 Engineering Drive 2, 117576 Singapore Mineral, Metal and Material Technology Centre, National University of Singapore, 9 Engineering Drive 1,117576 Singapore; E-Mail: mpeasm@.sg Author to whom correspondence should be addressed; E-Mail: chebke@.sg; Tel.: +65-6516-7132; Fax: +65-6779-1936. Received: 13 July 2011; in revised form: 10 August 2011 / Accepted: 22 August 2011 / Published: 25 August 2011 Abstract: This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demons