comparative analysis of mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints比较分析结核分枝杆菌的pe和ppe基因揭示高序列变异和明显缺乏选择性约束.pdfVIP

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comparative analysis of mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints比较分析结核分枝杆菌的pe和ppe基因揭示高序列变异和明显缺乏选择性约束.pdf

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comparative analysis of mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints比较分析结核分枝杆菌的pe和ppe基因揭示高序列变异和明显缺乏选择性约束

Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints 1 ¤a 1¤b ¨ 1 ¨ 2 1 Christopher R. E. McEvoy * , Ruben Cloete , Borna Muller , Anita C. Schurch , Paul D. van Helden , 3,4,5 1 1 Sebastien Gagneux , Robin M. Warren , Nicolaas C. Gey van Pittius 1 Department of Science and Technology, National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, Cape Town, South Africa, 2 Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment, Centre for Infectious Disease Control, (CIb/LIS, pb 22), Bilthoven, The Netherlands, 3 Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, 4 University of Basel, Basel, Switzerland, 5 Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, United Kingdom Abstract Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ ppe proteins remains enigmatic but studies suggest that they are secreted or cell surface associated and are involved in bacterial virulence. Previous studies have also shown that some pe/ppe genes are polymorphic, a finding that suggests involvement in antigenic variation. Using comparative sequence analysis of 18 publicly available MTBC whole genome sequences, we have performed alignments of 33 pe (excluding