biophysical cueing and vascular endothelial cell behavior生物物理暗示和血管内皮细胞的行为.pdfVIP

Materials 2010, 3, 1620-1639; doi:10.3390/ma3031620 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Biophysical Cueing and Vascular Endothelial Cell Behavior 1 2 1 2 Joshua A. Wood , Sara J. Liliensiek , Paul Russell , Paul F. Nealey and Christopher J. Murphy 1,3,* 1 Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA; E-Mails: jawood@ (J.A.W.); prussell@ (P.R.) 2 Department of Chemical and Biological Engineering, School of Engineering, University of Wisconsin-Madison, Madison, WI, USA; E-Mails: sjlilien@ (S.J.L.); nealey@ (P.F.N.) 3 Department of Opthalmology and Vision Sciences, School of Medicine, University of California, Davis, CA, USA * Author to whom correspondence should be addressed; E-Mail: cjmurphy@; Tel.: +1-530-752-0926; Fax: +1-530-752-6161. Received: 1 February 2010; in revised form: 25 February 2010 / Accepted: 4 March 2010 / Published: 5 March 2010 Abstract: Human vascular endothelial cells (VEC) line the vessels of the body and are critical for the maintenance of vessel integrity and trafficking of biochemical cues. They are fundamental structural elements and are central to the signaling environment. Alterations in the normal functioning of the VEC population are associated with a number of vascular disorders among which are some of the leading causes of death