biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male japanese population生物监测与等离子体相关的尿可替宁浓度水平的尼古丁代谢产物在男性每日吸烟后日本人口.pdfVIP
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biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male japanese population生物监测与等离子体相关的尿可替宁浓度水平的尼古丁代谢产物在男性每日吸烟后日本人口
Int. J. Environ. Res. Public Health 2010, 7, 2953-2964; doi:10.3390/ijerph7072953 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article Biomonitoring of Urinary Cotinine Concentrations Associated with Plasma Levels of Nicotine Metabolites after Daily Cigarette Smoking in a Male Japanese Population Taku Nagano 1, Makiko Shimizu 1, Kazuma Kiyotani 2, Tetsuya Kamataki 1,2, Ryohji Takano 1, Norie Murayama 1, Fumiaki Shono 3, and Hiroshi Yamazaki 1,4,* 1 Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan; E-Mails: p0910@g.shoyaku.ac.jp (T.N.); shimizu@ac.shoyaku.ac.jp (M.S.); takano.r@ (R.T.); muraya_n@ac.shoyaku.ac.jp (N.M.) 2 Hokkaido University, Sapporo 060-0182, Japan; E-Mails: kkiyotani@src.riken.jp (K.K); snc78123@ (T.K.) 3 Japan Chemical Industry Associations (JCIA), Tokyo 104-0033, Japan; E-Mail: fshono@jcia-net.or.jp (F.S.) 4 High Technology Research Center, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan * Author to whom correspondence should be addressed; E-Mail: hyamazak@ac.shoyaku.ac.jp; Tel.: +81-42-721-1406. Received: 1 June 2010; in revised form: 17 June 2010 / Accepted: 16 July 2010 / Published: 20 July 2010 Abstract: Human biomonitoring of plasma and urinary levels of nicotine, cotinine, and 3′-hydr
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