comorbid externalising behaviour in adhd evidence for a distinct pathological entity in adolescence共病外化行为adhd的证据明显病理实体在青春期.pdfVIP

Comorbid Externalising Behaviour in AD/HD: Evidence for a Distinct Pathological Entity in Adolescence 1 1 2 3,5 4 3 Sharnel Perera , David Crewther *, Rodney Croft , Hannah Keage , Daniel Hermens , C. Richard Clark 1 Brain Sciences Institute, Swinburne University of Technology, Melbourne, Victoria, Australia, 2 School of Psychology, University of Wollongong, Wollongong, New South Wales, Australia, 3 School of Psychology, Flinders University, Adelaide, South Australia, Australia, 4 Brain Dynamic Centre, University of Sydney, Sydney, New South Wales, Australia, 5 Cognitive Neuroscience Laboratory, School of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, South Australia, Australia Abstract While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants