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biomarkers in prostate cancer epidemiology生物标志物在前列腺癌流行病学
Cancers 2011, 3, 3773-3798; doi:10.3390/cancers3043773 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Biomarkers in Prostate Cancer Epidemiology Mukesh Verma 1,*, Payal Patel 1 and Mudit Verma 2 1 Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institues of Health (NIH), 6130 Executive Blvd., Rockville, MD 20852, USA; E-Mail: pvpatel@ 2 Laboratory of Cancer Biology and Genetics, Clinical Research Center, National Cancer Institute, National Institues of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA; E-Mail: mverma@ * Author to whom correspondence should be addressed; E-Mail: vermam@; Tel.: +1-301-594-7344; Fax: +1-301-435-5477. Received: 1 August 2011; in revised form: 26 September 2011 / Accepted: 26 September 2011 / Published: 30 September 2011 Abstract: Understanding the etiology of a disease such as prostate cancer may help in identifying populations at high risk, timely intervention of the disease, and proper treatment. Biomarkers, along with exposure history and clinical data, are useful tools to achieve these goals. Individual risk and population incidence of prostate cancer result from the intervention of genetic susceptibility and exposure. Biochemical, epigenetic, genetic, and imaging biomarkers are used to identify people at high risk for developing prostate cancer. In cancer
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