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biomarkers for basal-like breast cancer官腔乳腺癌生物标记
Cancers 2010, 2, 1040-1065; doi:10.3390/cancers2021040 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Biomarkers for Basal-like Breast Cancer Jennifer R. Choo and Torsten O. Nielsen * Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; E-Mail: jennchoo@interchange.ubc.ca * Author to whom correspondence should be addressed; E-Mail: torsten@interchange.ubc.ca; Tel.: +1-604-875-4111 ext. 66768; Fax: +1-604-875-4497. Received: 19 March 2010; in revised form: 11 May 2010 / Accepted: 19 May 2010 / Published: 28 May 2010 Abstract: Initially recognized through microarray-based gene expression profiling, basal- like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment. Keywords: breast cancer; basal-like; biomarkers; intrinsic subtype; immunohisto
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