biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats生物标志物脊髓损伤严重程度的大鼠的脑脊髓液.pdfVIP

Biomarkers for Severity of Spinal Cord Injury in the Cerebrospinal Fluid of Rats 3 1 1 2 1 3 Joanna M. Lubieniecka *, Femke Streijger , Jae H. T. Lee , Nikolay Stoynov , Jie Liu , Randy Mottus , 3,4 1,6 5 2 1,3 Tom Pfeifer , Brian K. Kwon , Jens R. Coorssen , Leonard J. Foster , Thomas A. Grigliatti *, Wolfram Tetzlaff1,3 1 International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre, University of British Columbia, Vancouver, British Columbia, Canada, 2 Centre for High-Throughput Biology and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, 3 Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, 4 Centre for Drug Research and Development (CDRD), University of British Columbia, Vancouver, British Columbia, Canada, 5 Molecular Physiology Department, School of Medicine, University of Western Sydney, Penrith, New South Wales, Australia, 6 Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada Abstract One of the major challenges in management of spinal cord injury (SCI) is that the assessment of injury severity is often imprecise. Identification of reliable, easily quantifiable biomarkers that delineate the severity of the initial injury and that have prognostic value for the degree of functional recovery would significantly aid the clinician in the choice of potential treatments. To find such biomarkers we performed quantitative liquid chromatography-mass spectrometry (LC-MS/M