biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients炎症生物标记、免疫抑制和压力与活动性疾病发现肺结核病人的代谢组学分析.pdfVIP

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biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients炎症生物标记、免疫抑制和压力与活动性疾病发现肺结核病人的代谢组学分析.pdf

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biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients炎症生物标记、免疫抑制和压力与活动性疾病发现肺结核病人的代谢组学分析

Biomarkers of Inflammation, Immunosuppression and Stress Are Revealed by Metabolomic Profiling of Tuberculosis Patients 1 . 1.¤a 1 2¤b January Weiner 3rd * , Shreemanta K. Parida , Jeroen Maertzdorf , Gillian F. Black , 3 3 4 1¤c 1 Dirk Repsilber , Anna Telaar , Robert P. Mohney , Cordelia Arndt-Sullivan , Christian A. Ganoza , ´ 1 2 1 Kellen C. Fae , Gerhard Walzl , Stefan H. E. Kaufmann * 1 Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, 2 Department of Biomedical Sciences, University of Stellenbosch, Cape Town, South Africa, 3 Biomathematics/Bioinformatics Group, Genetics and Biometry, Leibniz Institute for Farm Animal Biology, FBN, Dummerstorf, Germany, 4 Metabolon, Inc., Durham, North Carolina, United States of America Abstract Although tuberculosis (TB) causes more deaths than any other pathogen, most infected individuals harbor the pathogen without signs of disease. We explored the metabolome of .400 small molecules in serum of uninfected individuals, latently infected healthy individuals and patients with active TB. We identified changes in amino acid, lipid and nucleotide metabolism pathways, providing evidence for anti-inflammatory metabolomic changes in TB. Metabolic profiles indicate increased activity of indoleamine 2,3 dioxygenase 1 (IDO1), decreased phospholipase activity, increased abundance of adenosine metabolism products, as well as indicato