有哪些信誉好的足球投注网站biological function and molecular mapping of m antigen in yeast phase of histoplasma capsulatum生物功能和分子映射m抗原的荚膜组织胞浆菌的发酵阶段.pdfVIP
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biological function and molecular mapping of m antigen in yeast phase of histoplasma capsulatum生物功能和分子映射m抗原的荚膜组织胞浆菌的发酵阶段
Biological Function and Molecular Mapping of M Antigen in Yeast Phase of Histoplasma capsulatum ˜ 1,2 3 2,4 Allan Jefferson Guimaraes , Andrew John Hamilton , Herbert Leonel de M. Guedes , Joshua Daniel 1. ´ 2. Nosanchuk *, Rosely Maria Zancope-Oliveira 1 Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, ´ ´ ´ ˜ United States of America, 2 Laboratorio de Micologia - Setor de Imunodiagnostico - Instituto de Pesquisa Clınica Evandro Chagas, Fundac¸ao Oswaldo Cruz, Rio de Janeiro, ´ ´ ´ ´ Brazil, 3 St John’s Institute of Dermatology, Guy’s Hospital, King’s College, London, United Kingdom, 4 Laboratorio de Bioquımica de Proteınas e Peptıdeos, Instituto ˜ Oswaldo Cruz, Fundac¸ao Oswaldo Cruz, Rio de Janeiro, Brazil Abstract Histoplasmosis, due to the intracellular fungus Histoplasma capsulatum, can be diagnosed by demonstrating the presence of antibodies specific to the immunodominant M antigen. However, the role of this protein in the pathogenesis of histoplasmosis has not been elucidated. We sought to structurally and immunologically characterize the protein, determine yeast cell surface expression, and confirm
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