有哪些信誉好的足球投注网站antiretroviral simplification with darunavirritonavir monotherapy in routine clinical practice safety, effectiveness, and impact on lipid profile抗逆转录病毒的简化与darunavirritonavir单一疗法安全的日常临床实践效果,对血脂的影响.pdfVIP
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antiretroviral simplification with darunavirritonavir monotherapy in routine clinical practice safety, effectiveness, and impact on lipid profile抗逆转录病毒的简化与darunavirritonavir单一疗法安全的日常临床实践效果,对血脂的影响
Antiretroviral Simplification with Darunavir/Ritonavir
Monotherapy in Routine Clinical Practice: Safety,
Effectiveness, and Impact on Lipid Profile
´ 1,2 ´ ´ 1,2 1,2 1,2 1 1,3
Jose R. Santos *, Jose Molto , Josep M. Llibre , Eugenia Negredo , Isabel Bravo , Arelly Ornelas ,
Bonaventura Clotet1,4, Roger Paredes1,4
`
1 Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain, 2 Universitat Autonoma de Barcelona, Barcelona, Spain,
3 Department of Econometrics, Statistics and Spanish Economy, University of Barcelona, Barcelona, Spain, 4 IrsiCaixa Foundation, Barcelona, Spain
Abstract
Background: Simplification of antiretroviral treatment (ART) with darunavir/ritonavir (DRV/r) monotherapy has achieved
sustained suppression of plasma viral load (pVL) in clinical trials; however, its effectiveness and safety profile has not been
evaluated in routine clinical practice.
Methodology/Principal Findings: We performed a retrospective cohort analysis of HIV-1-infected patients who initiated
DRV/r monotherapy once daily with a pVL ,50 copies/mL under ART and at least 1 subsequent follow-up visit in our clinic.
The primary study endpoints were the percentage of patients with virological failure (VF, defined as 2 consecutive pVL .50
copies/mL) at week 48, and time to VF. Other causes of treatment discontinuation and changes in lipid profile were
evaluated up to week 48. Ninety-two patients were followed for a median (IQR) of 73 (57–92) weeks
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