有哪些信誉好的足球投注网站analysis of marker-defined hnscc subpopulations reveals a dynamic regulation of tumor initiating properties分析marker-defined hnscc亚种群显示了一个动态调节肿瘤启动属性.pdfVIP
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analysis of marker-defined hnscc subpopulations reveals a dynamic regulation of tumor initiating properties分析marker-defined hnscc亚种群显示了一个动态调节肿瘤启动属性
Analysis of Marker-Defined HNSCC Subpopulations
Reveals a Dynamic Regulation of Tumor Initiating
Properties
1,2 1,2 1,2 1,2 2
Paloma Bragado , Yeriel Estrada , Maria Soledad Sosa , Alvaro Avivar-Valderas , David Cannan ,
2 2 2 1 3,4
Eric Genden , Marita Teng , Aparna C. Ranganathan , Huei-Chi Wen , Avnish Kapoor , Emily
Bernstein3,4,5,6, Julio A. Aguirre-Ghiso1,2,5,6*
1 Division of Hematology and Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America, 2 Department of
Otolaryngology, Mount Sinai School of Medicine, New York, New York, United States of America, 3 Department of Oncological Sciences, Mount Sinai School of Medicine,
New York, New York, United States of America, 4 Department of Dermatology, Mount Sinai School of Medicine, New York, New York, United States of America, 5 Tisch
Cancer Institute, Mount Sinai School of Medicine, New York, New York, United States of America, 6 Black Family Stem Cell Institute, Mount Sinai School of Medicine, New
York, New York, United States of America
Abstract
Head and neck squamous carcinoma (HNSCC) tumors carry dismal long-term prognosis and the role of tumor initiating cells
(TICs) in this cancer is unclear. We investigated in HNSCC xenografts whether specific tumor subpopulations contributed to
tumor growth. We used a CFSE-based label retentions assay, CD49f (a6-integrin) surface levels and aldehyde dehydrogenase
(ALDH) activity to profile HNSCC subpopulations. The tumorigenic potential of marker-p
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