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antiproliferative activity of β-hydroxy-β-arylalkanoic acids抗增殖活动β-hydroxy-β-arylalkanoic酸
Int. J. Mol. Sci. 2007, 8, 214-228
International Journal of
Molecular Sciences
ISSN 1422-0067
© 2007 by MDPI
/ijms/
Antiproliferative Activity of ββ-Hydroxy-ββ-Arylalkanoic Acids
ββ ββ
1 2 2 2
Sanda P. Dilber , Željko S. Žižak ,Tatjana P. Stanojković , Zorica D. Juranić , Branko J.
3 4 *
Drakulić and Ivan O. Juranić
1 Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia; E-Mail:
sandad@pharmacy.bg.ac.yu
2 Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia; E-Mails:
zizakz@ncrc.ac.yu; stanojkovict@ncrc.ac.yu; juranicz@ncrc.ac.yu
3 Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000
Belgrade, Serbia; E-Mail: bdrakuli@chem.bg.ac.yu
4 Faculty of Chemistry, University of Belgrade, P.O. Box 158, 11001 Belgrade, Serbia; E-Mail:
ijuranic@chem.bg.ac.yu
* Author to whom correspondence should be addressed.
Received: 13 February 2007 / Accepted: 5 March 2007 / Published: 13 March 2007
Abstract: Article describes the synthesis of fifteen β-hydroxy-β-arylalkanoic acids by
Reformatsky reaction using the 1-ethoxyethyl-2-bromoalkanoates, aromatic or cycloalkyl
ketones or aromatic aldehydes. The short survey of previously
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