antiproliferative effect of aaptamine on human chronic myeloid leukemia k562 cells抗增殖效果aaptamine人类慢性骨髓性白血病k562细胞.pdfVIP

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antiproliferative effect of aaptamine on human chronic myeloid leukemia k562 cells抗增殖效果aaptamine人类慢性骨髓性白血病k562细胞.pdf

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antiproliferative effect of aaptamine on human chronic myeloid leukemia k562 cells抗增殖效果aaptamine人类慢性骨髓性白血病k562细胞

Int. J. Mol. Sci. 2011, 12, 7352-7359; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells Meihua Jin 1, Wennan Zhao 1, Yanwen Zhang 1, Motomasa Kobayashi 2, Hongquan Duan 1,* and Dexin Kong 1,* 1 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmaceutical Sciences and Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; E-Mails: jinmeihua@ (M.J.); wennan0719@ (W.Z.); zhangyanwen@ (Y.Z.) 2 Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan; E-Mail: kobayasi@phs.osaka-u.ac.jp * Authors to whom correspondence should be addressed; E-Mails: kongdexin@ (D.K.); duanhongquan@ (H.D.). Received: 26 September 2011; in revised form: 18 October 2011 / Accepted: 20 October 2011 / Published: 26 October 2011 Abstract: We previously isolated aaptamine, a benzonaphthyridine alkaloid, from marine sponge Aaptos suberitoids. In this study, we investigated the anti-proliferative effect of aaptamine on chronic myeloid leukemia (CML) K562 cells. Aaptamine inhibited growth of K562 with a GI50 as 10 μM, and arrested cell cycle at G2/M phase. Western blot analysis indicated that aaptamine induced p21 expression in K562 cells. Moreover, p21 promoter was activate